Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder

Leonardo F Fontenelle, Ben J Harrison, Jesus M Pujol, Christopher G Davey, Alex Fornito, Emre Bora, Christos Pantelis, Murat Yucel

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13 Citations (Scopus)

Abstract

Background: Obsessive-compulsive disorder (OCD) is associated with a range of emotional abnormalities linked to its defining symptoms, comorbid illnesses and cognitive deficits. The aim of this preliminary study was to examine functional changes in the brain that are associated with experimentally induced sad mood in patients with OCD compared with healthy controls in a frontolimbic circuit relevant to both OCD and mood regulation.Methods: Participants underwent a validated sad mood induction procedure during functional magnetic resonance imaging. Analyses focused on mapping changes in the functional connectivity of the subgenual anterior cingulate cortex (ACC) within and between the 2 groups in response to successfully induced sadness.Results: We enrolled 11 patients with OCD and 10 age-, sex- and IQ-matched controls in our study. Unlike controls, patients with OCD did not demonstrate predicted increases in functional connectivity between the subgenual ACC and other frontal regions during mood induction. Instead, patients demonstrated heightened connectivity between the subgenual ACC and ventral caudate/nucleus accumbens region and the hypothalamus
Original languageEnglish
Pages (from-to)231-240
Number of pages10
JournalJournal of Psychiatry & Neuroscience
Volume37
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

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