Brain Feeding Circuits after Roux-en-Y Gastric Bypass

Mohammed K. Hankir, Florian Seyfried, Alexander D. Miras, Michael A. Cowley

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)


Metabolic surgical procedures, such as Roux-en-Y gastric bypass (RYGB), uniquely reprogram feeding behavior and body weight in obese subjects. Clinical neuroimaging and animal studies are only now beginning to shed light on some of the underlying central mechanisms. We present here the roles of key brain neurotransmitter/neuromodulator systems in food choice, value, and intake at various stages after RYGB. In doing so, we elaborate on how known signals emanating from the reorganized gut, including peptide hormones and microbiota products, impinge on newly mapped homeostatic and hedonic brain feeding circuits. Continued progress in the rapidly evolving field of metabolic surgery will inform the design of more effective weight-loss compounds.

Original languageEnglish
Pages (from-to)218-237
Number of pages20
JournalTrends in Endocrinology and Metabolism
Issue number4
Publication statusPublished - 1 Apr 2018


  • brain feeding circuits
  • feeding behavior
  • functional magnetic resonance imaging
  • gastrointestinal tract
  • positron emission tomography
  • Roux-en-Y gastric bypass

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