Brain, fat and the immune system: A multidirectional communication network controlling energy homeostasis

Laurence Macia, C Verwaerde, Odile Viltart, Nicolas Salome, Jerome Mairesse, Myriam Delacre, Isabelle Wolowczuk

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1 Citation (Scopus)


It is known since long that energy homeostasis is maintained by multiple mechanisms allowing the brain to sense the nutritional status of the body and adapt behavioral and metabolic responses to changes in fuel availability. In addition, the immune system is also largely dependent on the body s nutritional status and over the last decade, an abundance of evidence has emerged, demonstrating the close link between metabolism and immunity. Moreover, the brain and the immune system communicate through neurotransmitters, cytokines and endocrine hormones. Therefore nervous, endocrine and immune systems represent a complex network of communication ultimately controlling energy homeostasis. This review is an attempt to summarize these multiple and complex regulatory pathways.
Original languageEnglish
Pages (from-to)113 - 136
Number of pages24
JournalCurrent Trends in Immunology
Publication statusPublished - 2006
Externally publishedYes

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