Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study

Ernest Van Veen; Mathieu Van Der Jagt; Maryse C. Cnossen; Andrew I.R. Maas; Inez D. De Beaufort; David K. Menon; Giuseppe Citerio; Nino Stocchetti; Wim J.R. Rietdijk; Jeroen T.J.M. Van Dijck; Erwin J.O. Kompanje; the CENTER-TBI investigators and participants

doi:10.1186/s13054-018-2241-4

Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study

Ernest Van Veen, Mathieu Van Der Jagt, Maryse C. Cnossen, Andrew I.R. Maas, Inez D. De Beaufort, David K. Menon, Giuseppe Citerio, Nino Stocchetti, Wim J.R. Rietdijk, Jeroen T.J.M. Van Dijck, Erwin J.O. Kompanje, the CENTER-TBI investigators and participants

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

Original language	English
Article number	306
Number of pages	11
Journal	Critical Care
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s13054-018-2241-4
Publication status	Published - 16 Nov 2018

Keywords

Brain death
Ethics
Postmortem organ donation
Traumatic brain injury
Ventricular drainage
Withdrawing life-sustaining measures

Access to Document

10.1186/s13054-018-2241-4Licence: CC BY

301888859-oaFinal published version, 428 KBLicence: CC BY

Link to publication in Scopus

Cite this

Van Veen, E., Van Der Jagt, M., Cnossen, M. C., Maas, A. I. R., De Beaufort, I. D., Menon, D. K., Citerio, G., Stocchetti, N., Rietdijk, W. J. R., Van Dijck, J. T. J. M., Kompanje, E. J. O., & the CENTER-TBI investigators and participants (2018). Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study. Critical Care, 22(1), [306]. https://doi.org/10.1186/s13054-018-2241-4

Van Veen, Ernest ; Van Der Jagt, Mathieu ; Cnossen, Maryse C. ; Maas, Andrew I.R. ; De Beaufort, Inez D. ; Menon, David K. ; Citerio, Giuseppe ; Stocchetti, Nino ; Rietdijk, Wim J.R. ; Van Dijck, Jeroen T.J.M. ; Kompanje, Erwin J.O. ; the CENTER-TBI investigators and participants. / Brain death and postmortem organ donation : Report of a questionnaire from the CENTER-TBI study. In: Critical Care. 2018 ; Vol. 22, No. 1.

@article{351320a77e224d86a5830324154dc6ae,

title = "Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study",

abstract = "Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.",

keywords = "Brain death, Ethics, Postmortem organ donation, Traumatic brain injury, Ventricular drainage, Withdrawing life-sustaining measures",

author = "{Van Veen}, Ernest and {Van Der Jagt}, Mathieu and Cnossen, {Maryse C.} and Maas, {Andrew I.R.} and {De Beaufort}, {Inez D.} and Menon, {David K.} and Giuseppe Citerio and Nino Stocchetti and Rietdijk, {Wim J.R.} and {Van Dijck}, {Jeroen T.J.M.} and Kompanje, {Erwin J.O.} and Cecilia Ackerlund and Hadie Adams and Vanni Agnoletti and Judith Allanson and Krisztina Amrein and Norberto Andaluz and Nada Andelic and Lasse Andreassen and Azasevac Antun and Audny Anke and Anna Antoni and Hilko Ardon and G{\'e}rard Audibert and Kaspars Auslands and Philippe Azouvi and Azzolini, {Maria Luisa} and Camelia Baciu and Rafael Badenes and Ronald Bartels and P{\'a}l Barz{\'o} and Ursula Bauerfeind and Romuald Beauvais and Ronny Beer and Francisco, {Javier Belda} and Bellander, {Bo Michael} and Antonio Belli and R{\'e}my Bellier and Habib Benali and Thierry Benard and Maurizio Berardino and Luigi Beretta and Christopher Beynon and Federico Bilotta and Harald Binder and Erta Biqiri and Morten Blaabjerg and {Den Boogert}, Hugo and Pierre Bouzat and Peter Bragge and Alexandra Brazinova and Vibeke Brinck and Joanne Brooker and Camilla Brorsson and Andras Buki and Monika Bullinger and Emiliana Calappi and Calvi, {Maria Rosa} and Peter Cameron and Lozano, {Guillermo Carbayo} and Marco Carbonara and Elsa Carise and K. Carpenter and Casta{\~n}o-Le{\'o}n, {Ana M.} and Francesco Causin and Giorgio Chevallard and Arturo Chieregato and Mark Coburn and Jonathan Coles and Lizzie Coles-Kemp and Johnny Collett and Cooper, {Jamie D.} and Marta Correia and Amra Covic and Nicola Curry and Endre Czeiter and Marek Czosnyka and Claire Dahyot-Fizelier and Fran{\c c}ois Damas and Pierre Damas and Helen Dawes and {De Keyser}, V{\'e}ronique and {Della Corte}, Francesco and Bart Depreitere and {De Ruiter Godard}, {C. W.} and Dula Dilvesi and Shenghao Ding and Diederik Dippel and Abhishek Dixit and Emma Donoghue and Jens Dreier and Duli{\`e}re, {Guy Loup} and George Eapen and Heiko Engemann and Ari Ercole and Patrick Esser and Erzs{\'e}bet Ezer and Martin Fabricius and Feigin, {Valery L.} and Junfeng Feng and Kelly Foks and Francesca Fossi and Gilles Francony and Ulderico Freo and Shirin Frisvold and Alex Furmanov and Pablo Gagliardo and Damien Galanaud and Dashiell Gantner and Guoyi Gao and Karin Geleijns and Pradeep George and Alexandre Ghuysen and Lelde Giga and Benoit Giraud and Ben Glocker and Jagos Golubovic and Gomez, {Pedro A.} and Francesca Grossi and Gruen, {Russell L.} and Deepak Gupta and Haagsma, {Juanita A.} and Iain Haitsma and Hartings, {Jed A.} and Raimund Helbok and Eirik Helseth and Daniel Hertle and Astrid Hoedemaekers and Stefan Hoefer and Lindsay Horton and Jilske Huijben and Hutchinson, {Peter J.} and H{\aa}berg, {Asta Kristine} and Bram Jacobs and Stefan Jankowski and Mike Jarrett and Bojan Jelaca and Jiang, {Ji Yao} and Kelly Jones and Konstantinos Kamnitsas and Mladen Karan and Ari Katila and Maija Kaukonen and Thomas Kerforne and Riku Kivisaari and Kolias, {Angelos G.} and B{\'a}lint Kolumb{\'a}n and Ksenija Kolundzija and Daniel Kondziella and Koskinen, {Lars Owe} and No{\'e}mi Kov{\'a}cs and Alfonso Lagares and Linda Lanyon and Steven Laureys and Fiona Lecky and Christian Ledig and Rolf Lefering and Valerie Legrand and Jin Lei and Leon Levi and Roger Lightfoot and Hester Lingsma and Dirk Loeckx and Angels Lozano and Stephen MacDonald and Marc Maegele and Marek Majdan and Sebastian Major and Alex Manara and Geoffrey Manley and Martin Didier and Martin, {Leon Francisco} and Costanza Martino and Armando Maruenda and Hugues Mar{\'e}chal and Alessandro Masala and Julia Mattern and Charles McFadyen and Catherine McMahon and B{\'e}la Melegh and Tomas Menovsky and Cristina Morganti-Kossmann and Davide Mulazzi and Visakh Muraleedharan and Lynnette Murray and Holger M{\"u}hlan and Nandesh Nair and Ancuta Negru and David Nelson and Virginia Newcombe and Daan Nieboer and Quentin Noirhomme and J{\'o}zsef Nyir{\'a}di and Mauro Oddo and Annemarie Oldenbeuving and Matej Oresic and Fabrizio Ortolano and Aarno Palotie and Parizel, {Paul M.} and Adriana Patruno and Payen, {Jean Fran{\c c}ois} and Natascha Perera and Vincent Perlbarg and Paolo Persona and Wilco Peul and Anna Piippo-Karjalainen and Floury, {S{\'e}bastien Pili} and Matti Pirinen and Horia Ples and Poca, {Maria Antonia} and Suzanne Polinder and Inigo Pomposo and Jussi Posti and Louis Puybasset and Andreea Radoi and Arminas Ragauskas and Rahul Raj and Malinka Rambadagalla and Ruben Real and Veronika Rehor{\v c}{\'i}kov{\'a} and Jonathan Rhodes and Samuli Ripatti and Saulius Rocka and Cecilie Roe and Olav Roise and Gerwin Roks and Jonathan Rosand and Jeffrey Rosenfeld and Christina Rosenlund and Guy Rosenthal and Rolf Rossaint and Sandra Rossi and Daniel Rueckert and Martin Rusn{\'a}k and Marco Sacchi and Barbara Sahakian and Juan Sahuquillo and Oliver Sakowitz and Francesca Sala and Renan Sanchez-Porras and Janos Sandor and Edgar Santos and Luminita Sasu and Davide Savo and Nadine Sch{\"a}ffer and Inger Schipper and Barbara Schl{\"o}{\ss}er and Anneliese Synnot and Tony Trapani and Shirley Vallance and {the CENTER-TBI investigators and participants}",

year = "2018",

month = nov,

day = "16",

doi = "10.1186/s13054-018-2241-4",

language = "English",

volume = "22",

journal = "Critical Care",

issn = "1364-8535",

publisher = "BioMed Central",

number = "1",

}

Van Veen, E, Van Der Jagt, M, Cnossen, MC, Maas, AIR, De Beaufort, ID, Menon, DK, Citerio, G, Stocchetti, N, Rietdijk, WJR, Van Dijck, JTJM, Kompanje, EJO & the CENTER-TBI investigators and participants 2018, 'Brain death and postmortem organ donation: Report of a questionnaire from the CENTER-TBI study', Critical Care, vol. 22, no. 1, 306. https://doi.org/10.1186/s13054-018-2241-4

Brain death and postmortem organ donation : Report of a questionnaire from the CENTER-TBI study. / Van Veen, Ernest; Van Der Jagt, Mathieu; Cnossen, Maryse C.; Maas, Andrew I.R.; De Beaufort, Inez D.; Menon, David K.; Citerio, Giuseppe; Stocchetti, Nino; Rietdijk, Wim J.R.; Van Dijck, Jeroen T.J.M.; Kompanje, Erwin J.O.; the CENTER-TBI investigators and participants.

In: Critical Care, Vol. 22, No. 1, 306, 16.11.2018.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Brain death and postmortem organ donation

T2 - Report of a questionnaire from the CENTER-TBI study

AU - Van Veen, Ernest

AU - Van Der Jagt, Mathieu

AU - Cnossen, Maryse C.

AU - Maas, Andrew I.R.

AU - De Beaufort, Inez D.

AU - Menon, David K.

AU - Citerio, Giuseppe

AU - Stocchetti, Nino

AU - Rietdijk, Wim J.R.

AU - Van Dijck, Jeroen T.J.M.

AU - Kompanje, Erwin J.O.

AU - Ackerlund, Cecilia

AU - Adams, Hadie

AU - Agnoletti, Vanni

AU - Allanson, Judith

AU - Amrein, Krisztina

AU - Andaluz, Norberto

AU - Andelic, Nada

AU - Andreassen, Lasse

AU - Antun, Azasevac

AU - Anke, Audny

AU - Antoni, Anna

AU - Ardon, Hilko

AU - Audibert, Gérard

AU - Auslands, Kaspars

AU - Azouvi, Philippe

AU - Azzolini, Maria Luisa

AU - Baciu, Camelia

AU - Badenes, Rafael

AU - Bartels, Ronald

AU - Barzó, Pál

AU - Bauerfeind, Ursula

AU - Beauvais, Romuald

AU - Beer, Ronny

AU - Francisco, Javier Belda

AU - Bellander, Bo Michael

AU - Belli, Antonio

AU - Bellier, Rémy

AU - Benali, Habib

AU - Benard, Thierry

AU - Berardino, Maurizio

AU - Beretta, Luigi

AU - Beynon, Christopher

AU - Bilotta, Federico

AU - Binder, Harald

AU - Biqiri, Erta

AU - Blaabjerg, Morten

AU - Den Boogert, Hugo

AU - Bouzat, Pierre

AU - Bragge, Peter

AU - Brazinova, Alexandra

AU - Brinck, Vibeke

AU - Brooker, Joanne

AU - Brorsson, Camilla

AU - Buki, Andras

AU - Bullinger, Monika

AU - Calappi, Emiliana

AU - Calvi, Maria Rosa

AU - Cameron, Peter

AU - Lozano, Guillermo Carbayo

AU - Carbonara, Marco

AU - Carise, Elsa

AU - Carpenter, K.

AU - Castaño-León, Ana M.

AU - Causin, Francesco

AU - Chevallard, Giorgio

AU - Chieregato, Arturo

AU - Coburn, Mark

AU - Coles, Jonathan

AU - Coles-Kemp, Lizzie

AU - Collett, Johnny

AU - Cooper, Jamie D.

AU - Correia, Marta

AU - Covic, Amra

AU - Curry, Nicola

AU - Czeiter, Endre

AU - Czosnyka, Marek

AU - Dahyot-Fizelier, Claire

AU - Damas, François

AU - Damas, Pierre

AU - Dawes, Helen

AU - De Keyser, Véronique

AU - Della Corte, Francesco

AU - Depreitere, Bart

AU - De Ruiter Godard, C. W.

AU - Dilvesi, Dula

AU - Ding, Shenghao

AU - Dippel, Diederik

AU - Dixit, Abhishek

AU - Donoghue, Emma

AU - Dreier, Jens

AU - Dulière, Guy Loup

AU - Eapen, George

AU - Engemann, Heiko

AU - Ercole, Ari

AU - Esser, Patrick

AU - Ezer, Erzsébet

AU - Fabricius, Martin

AU - Feigin, Valery L.

AU - Feng, Junfeng

AU - Foks, Kelly

AU - Fossi, Francesca

AU - Francony, Gilles

AU - Freo, Ulderico

AU - Frisvold, Shirin

AU - Furmanov, Alex

AU - Gagliardo, Pablo

AU - Galanaud, Damien

AU - Gantner, Dashiell

AU - Gao, Guoyi

AU - Geleijns, Karin

AU - George, Pradeep

AU - Ghuysen, Alexandre

AU - Giga, Lelde

AU - Giraud, Benoit

AU - Glocker, Ben

AU - Golubovic, Jagos

AU - Gomez, Pedro A.

AU - Grossi, Francesca

AU - Gruen, Russell L.

AU - Gupta, Deepak

AU - Haagsma, Juanita A.

AU - Haitsma, Iain

AU - Hartings, Jed A.

AU - Helbok, Raimund

AU - Helseth, Eirik

AU - Hertle, Daniel

AU - Hoedemaekers, Astrid

AU - Hoefer, Stefan

AU - Horton, Lindsay

AU - Huijben, Jilske

AU - Hutchinson, Peter J.

AU - Håberg, Asta Kristine

AU - Jacobs, Bram

AU - Jankowski, Stefan

AU - Jarrett, Mike

AU - Jelaca, Bojan

AU - Jiang, Ji Yao

AU - Jones, Kelly

AU - Kamnitsas, Konstantinos

AU - Karan, Mladen

AU - Katila, Ari

AU - Kaukonen, Maija

AU - Kerforne, Thomas

AU - Kivisaari, Riku

AU - Kolias, Angelos G.

AU - Kolumbán, Bálint

AU - Kolundzija, Ksenija

AU - Kondziella, Daniel

AU - Koskinen, Lars Owe

AU - Kovács, Noémi

AU - Lagares, Alfonso

AU - Lanyon, Linda

AU - Laureys, Steven

AU - Lecky, Fiona

AU - Ledig, Christian

AU - Lefering, Rolf

AU - Legrand, Valerie

AU - Lei, Jin

AU - Levi, Leon

AU - Lightfoot, Roger

AU - Lingsma, Hester

AU - Loeckx, Dirk

AU - Lozano, Angels

AU - MacDonald, Stephen

AU - Maegele, Marc

AU - Majdan, Marek

AU - Major, Sebastian

AU - Manara, Alex

AU - Manley, Geoffrey

AU - Didier, Martin

AU - Martin, Leon Francisco

AU - Martino, Costanza

AU - Maruenda, Armando

AU - Maréchal, Hugues

AU - Masala, Alessandro

AU - Mattern, Julia

AU - McFadyen, Charles

AU - McMahon, Catherine

AU - Melegh, Béla

AU - Menovsky, Tomas

AU - Morganti-Kossmann, Cristina

AU - Mulazzi, Davide

AU - Muraleedharan, Visakh

AU - Murray, Lynnette

AU - Mühlan, Holger

AU - Nair, Nandesh

AU - Negru, Ancuta

AU - Nelson, David

AU - Newcombe, Virginia

AU - Nieboer, Daan

AU - Noirhomme, Quentin

AU - Nyirádi, József

AU - Oddo, Mauro

AU - Oldenbeuving, Annemarie

AU - Oresic, Matej

AU - Ortolano, Fabrizio

AU - Palotie, Aarno

AU - Parizel, Paul M.

AU - Patruno, Adriana

AU - Payen, Jean François

AU - Perera, Natascha

AU - Perlbarg, Vincent

AU - Persona, Paolo

AU - Peul, Wilco

AU - Piippo-Karjalainen, Anna

AU - Floury, Sébastien Pili

AU - Pirinen, Matti

AU - Ples, Horia

AU - Poca, Maria Antonia

AU - Polinder, Suzanne

AU - Pomposo, Inigo

AU - Posti, Jussi

AU - Puybasset, Louis

AU - Radoi, Andreea

AU - Ragauskas, Arminas

AU - Raj, Rahul

AU - Rambadagalla, Malinka

AU - Real, Ruben

AU - Rehorčíková, Veronika

AU - Rhodes, Jonathan

AU - Ripatti, Samuli

AU - Rocka, Saulius

AU - Roe, Cecilie

AU - Roise, Olav

AU - Roks, Gerwin

AU - Rosand, Jonathan

AU - Rosenfeld, Jeffrey

AU - Rosenlund, Christina

AU - Rosenthal, Guy

AU - Rossaint, Rolf

AU - Rossi, Sandra

AU - Rueckert, Daniel

AU - Rusnák, Martin

AU - Sacchi, Marco

AU - Sahakian, Barbara

AU - Sahuquillo, Juan

AU - Sakowitz, Oliver

AU - Sala, Francesca

AU - Sanchez-Porras, Renan

AU - Sandor, Janos

AU - Santos, Edgar

AU - Sasu, Luminita

AU - Savo, Davide

AU - Schäffer, Nadine

AU - Schipper, Inger

AU - Schlößer, Barbara

AU - Synnot, Anneliese

AU - Trapani, Tony

AU - Vallance, Shirley

AU - the CENTER-TBI investigators and participants

PY - 2018/11/16

Y1 - 2018/11/16

N2 - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

AB - Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

KW - Brain death

KW - Ethics

KW - Postmortem organ donation

KW - Traumatic brain injury

KW - Ventricular drainage

KW - Withdrawing life-sustaining measures

UR - http://www.scopus.com/inward/record.url?scp=85056714365&partnerID=8YFLogxK

U2 - 10.1186/s13054-018-2241-4

DO - 10.1186/s13054-018-2241-4

M3 - Article

C2 - 30446017

AN - SCOPUS:85056714365

VL - 22

JO - Critical Care

JF - Critical Care

SN - 1364-8535

IS - 1

M1 - 306

ER -