Brain Connectivity Exposed by Anisotropic X-ray Dark-field Tomography

Matthias Wieczorek, Florian Schaff, Christoph Jud, Daniela Pfeiffer, Franz Pfeiffer, Tobias Lasser

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)


To understand the interaction of different parts of the human brain it is essential to know how they are connected. Such connections are predominantly related to the brain’s white matter, which forms the neuronal pathways, the axons. These axons, also referred to as nerve fibers, have a size on the micrometer scale and are therefore too small to be imaged by standard X-ray systems. In this paper, we use a grating interferometer and a method based on Anisotropic X-ray Dark-field Tomography (AXDT) with the goal to generate a three-dimensional tomographic reconstruction of these functional structures. A first preclinical survey shows that we successfully reconstruct the orientations of the brain fibers connectivity with our approach.

Original languageEnglish
Article number14345
Number of pages6
JournalScientific Reports
Issue number1
Publication statusPublished - 25 Sept 2018
Externally publishedYes

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