Brønsted Acid-Catalyzed Cyclization of β-Amino-1,4-enols to Oxazol-2(3H)-ones and 5-Alkenyloxazolidin-2-ones

Yichao Zhao, Stuart Adam Henry, Jianwen Jin, Guy James Clarkson, Philip Wai Hong Chan

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A synthetic method to prepare oxazol-2(3H)-ones and 5-alkenyloxazolidin-2-ones efficiently that relies on a Brønsted acid-catalyzed cyclization of the respective secondary and tertiary β-amino-1,4-enols in ethanol is described. The reaction did not require the exclusion of air or moisture.

Original languageEnglish
Pages (from-to)1029-1032
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 2019

Keywords

  • alcohols
  • Brønsted acids
  • cyclization
  • heterocycles
  • synthetic methods

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