Abstract
A highly efficient synthetic method to prepare 1,2-dihydroquinolines that relies on trifluoromethanesulfonic acid (TfOH)-catalysed allylic amination of 1-(2-aminoaryl)prop-2-en-1-ols is described. Achieved at a catalyst loading of 0.01 mol-% under mild conditions at room temperature, the reaction was found to be robust, with a wide range of substitution patterns tolerated. The corresponding N-heterocyclic adducts were obtained in good to excellent yields of 45-93 %.
Original language | English |
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Pages (from-to) | 673-681 |
Number of pages | 9 |
Journal | Australian Journal of Chemistry |
Volume | 71 |
Issue number | 9 |
DOIs | |
Publication status | Published - 19 Jun 2018 |