TY - JOUR
T1 - Bovine babesiosis in the 21st century: advances in biology and functional genomics
AU - Gohil, Sejal
AU - Herrmann, Susann
AU - Gunther, Svenja
AU - Cooke, Brian Mark
PY - 2013
Y1 - 2013
N2 - Bovine babesiosis caused by the protozoan parasite, Babesia bovis, remains a significant cause of avoidable economic losses to the livestock industry in many countries throughout the world. The molecular mechanisms underlying the pathophysiology of severe disease in susceptible cattle are not well understood and the tools available to study the biology of the parasite, including technologies for genetic manipulation, have only recently been developed. Recent availability of multiple parasite genomes and bioinformatic tools, in combination with the development of new biological reagents, will facilitate our better understanding of the parasite. This will ultimately assist in the identification of novel targets for the development of new therapeutics and vaccines. Here we describe some recent advances in Babesia research and highlight some important challenges for the future.
AB - Bovine babesiosis caused by the protozoan parasite, Babesia bovis, remains a significant cause of avoidable economic losses to the livestock industry in many countries throughout the world. The molecular mechanisms underlying the pathophysiology of severe disease in susceptible cattle are not well understood and the tools available to study the biology of the parasite, including technologies for genetic manipulation, have only recently been developed. Recent availability of multiple parasite genomes and bioinformatic tools, in combination with the development of new biological reagents, will facilitate our better understanding of the parasite. This will ultimately assist in the identification of novel targets for the development of new therapeutics and vaccines. Here we describe some recent advances in Babesia research and highlight some important challenges for the future.
UR - http://www.sciencedirect.com/science/article/pii/S0020751912002317
U2 - 10.1016/j.ijpara.2012.09.008
DO - 10.1016/j.ijpara.2012.09.008
M3 - Article
SN - 0020-7519
VL - 43
SP - 125
EP - 132
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 2
ER -