Botulinum toxin type a in children and adolescents with severe cerebral palsy: A retrospective chart review

Ronit Mesterman, Jan Willem Gorter, Adrienne Harvey, Julia Lockhart, Jenny McEwen-Hill, Karen Margallo, Nancy Goldie

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11 Citations (Scopus)


This retrospective cohort study reviewed set goals and their outcomes of children and adolescents with severe cerebral palsy who received botulinum toxin A in 2008 and 2009. Sixty children (36 male, mean age 9 years) were included. They received on average 4 (range 1-7) treatments, with the dosage varying between 20 and 400 units per treatment (3-21 U/kg/body weight). Mild transient side effects were reported in 12 of 242 treatments with botulinum toxin A. Treatment goals were related to lower limb function (82%), range of motion (68%), positioning (33%), upper limb function (33%), and facilitating ease of care in dressing (30%), toileting, and diapering (22%). The treatment goals were reached in 60% to 85% by report of the parent and child dyad. Our findings suggest that botulinum toxin A should be considered as a treatment option in patients with cerebral palsy within Gross Motor Function Classification System levels IV and V.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalJournal of Child Neurology
Issue number2
Publication statusPublished - 1 Feb 2014
Externally publishedYes


  • botulinum toxin A
  • cerebral palsy
  • children
  • hypertonia treatment
  • outcome

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