Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis

Chetana Pak, Philip J. Marriott, Peter D. Carpenter, R. Gary Amiet

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Abstract

A buffer system of borate with charged (carboxymethyl-β-CD) and uncharged (β-CD) cyclodextrins (CDs) was employed in the chiral resolution and separation of propranolol and its selected major metabolites. By appropriate choice of buffer and additive conditions, chiral resolution of all of the compounds studied was achieved in a single analysis, where near baseline resolution was found for the difficult to resolve propranolol- glycol (Pr-glycol). This has not been observed in previous studies of propranolol and its metabolites.

Original languageEnglish
Pages (from-to)640-644
Number of pages5
JournalHRC Journal of High Resolution Chromatography
Volume21
Issue number12
DOIs
Publication statusPublished - 1 Jan 1998
Externally publishedYes

Keywords

  • Borate complexation
  • Capillary eIectrophoresis
  • Chiral separation
  • Propranolol and its metabolites
  • Uncharged and charged cyclodextrin

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