Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis

Chetana Pak; Philip J. Marriott; Peter D. Carpenter; R. Gary Amiet

doi:10.1002/(SICI)1521-4168(19981201)21:12<640::AID-JHRC640>3.0.CO;2-Q

Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis

Chetana Pak, Philip J. Marriott, Peter D. Carpenter, R. Gary Amiet

Research output: Contribution to journal › Article › Research › peer-review

15 Citations (Scopus)

Abstract

A buffer system of borate with charged (carboxymethyl-β-CD) and uncharged (β-CD) cyclodextrins (CDs) was employed in the chiral resolution and separation of propranolol and its selected major metabolites. By appropriate choice of buffer and additive conditions, chiral resolution of all of the compounds studied was achieved in a single analysis, where near baseline resolution was found for the difficult to resolve propranolol- glycol (Pr-glycol). This has not been observed in previous studies of propranolol and its metabolites.

Original language	English
Pages (from-to)	640-644
Number of pages	5
Journal	HRC Journal of High Resolution Chromatography
Volume	21
Issue number	12
DOIs	https://doi.org/10.1002/(SICI)1521-4168(19981201)21:12<640::AID-JHRC640>3.0.CO;2-Q
Publication status	Published - 1 Jan 1998
Externally published	Yes

Keywords

Borate complexation
Capillary eIectrophoresis
Chiral separation
Propranolol and its metabolites
Uncharged and charged cyclodextrin

Cite this

Pak, C., Marriott, P. J., Carpenter, P. D., & Amiet, R. G. (1998). Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis. HRC Journal of High Resolution Chromatography, 21(12), 640-644. https://doi.org/10.1002/(SICI)1521-4168(19981201)21:12<640::AID-JHRC640>3.0.CO;2-Q

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Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis. / Pak, Chetana; Marriott, Philip J.; Carpenter, Peter D.; Amiet, R. Gary.

In: HRC Journal of High Resolution Chromatography, Vol. 21, No. 12, 01.01.1998, p. 640-644.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Borate complexation and mixed cyclodextrin additives for chiral separation of propranolol and its metabolites by capillary electrophoresis

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AB - A buffer system of borate with charged (carboxymethyl-β-CD) and uncharged (β-CD) cyclodextrins (CDs) was employed in the chiral resolution and separation of propranolol and its selected major metabolites. By appropriate choice of buffer and additive conditions, chiral resolution of all of the compounds studied was achieved in a single analysis, where near baseline resolution was found for the difficult to resolve propranolol- glycol (Pr-glycol). This has not been observed in previous studies of propranolol and its metabolites.

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Access to Document

10.1002/(SICI)1521-4168(19981201)21:12<640::AID-JHRC640>3.0.CO;2-Q

Link to publication in Scopus