Abstract
A buffer system of borate with charged (carboxymethyl-β-CD) and uncharged (β-CD) cyclodextrins (CDs) was employed in the chiral resolution and separation of propranolol and its selected major metabolites. By appropriate choice of buffer and additive conditions, chiral resolution of all of the compounds studied was achieved in a single analysis, where near baseline resolution was found for the difficult to resolve propranolol- glycol (Pr-glycol). This has not been observed in previous studies of propranolol and its metabolites.
Original language | English |
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Pages (from-to) | 640-644 |
Number of pages | 5 |
Journal | HRC Journal of High Resolution Chromatography |
Volume | 21 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1 Jan 1998 |
Externally published | Yes |
Keywords
- Borate complexation
- Capillary eIectrophoresis
- Chiral separation
- Propranolol and its metabolites
- Uncharged and charged cyclodextrin