TY - JOUR
T1 - Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine
AU - Cosgrove, Catherine A.
AU - Castello-Branco, Luiz R.R.
AU - Hussell, Tracy
AU - Sexton, Amy
AU - Giemza, Rafaela
AU - Phillips, Richard
AU - Williams, Andrew
AU - Griffin, George E.
AU - Dougan, Gordon
AU - Lewis, David J.M.
PY - 2006/4/1
Y1 - 2006/4/1
N2 - Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
AB - Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
UR - http://www.scopus.com/inward/record.url?scp=33645523972&partnerID=8YFLogxK
U2 - 10.1128/IAI.74.4.2449-2452.2006
DO - 10.1128/IAI.74.4.2449-2452.2006
M3 - Article
C2 - 16552077
AN - SCOPUS:33645523972
SN - 0019-9567
VL - 74
SP - 2449
EP - 2452
JO - Infection and Immunity
JF - Infection and Immunity
IS - 4
ER -
