Boosting of cellular immunity against Mycobacterium tuberculosis and modulation of skin cytokine responses in healthy human volunteers by Mycobacterium bovis BCG substrain Moreau Rio de Janeiro oral vaccine

Catherine A. Cosgrove, Luiz R.R. Castello-Branco, Tracy Hussell, Amy Sexton, Rafaela Giemza, Richard Phillips, Andrew Williams, George E. Griffin, Gordon Dougan, David J.M. Lewis

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Abstract

Oral immunization of healthy adults with 107 CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.

Original languageEnglish
Pages (from-to)2449-2452
Number of pages4
JournalInfection and Immunity
Volume74
Issue number4
DOIs
Publication statusPublished - 1 Apr 2006
Externally publishedYes

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