Bone marrow transplant from Gpr21-/- mice inhibits the ex vivo migration of mouse immune cells

Research output: Contribution to conferencePoster

Original languageEnglish
Publication statusPublished - 2018
EventOrgan Crosstalk in Obesity and NAFLD (J3): joint with the meeting on Bioenergetics and Metabolic Disease (J4) - Keystone Resort, Keystone, United States of America
Duration: 21 Jan 201825 Jan 2018


ConferenceOrgan Crosstalk in Obesity and NAFLD (J3)
Country/TerritoryUnited States of America
OtherNeural and humoral communication among peripheral organs and the brain is critical in coordinating whole body energy homeostasis in health and disease. Nutrient and hormone sensing take place in multiple organs with the central nervous system as a site of integration of these diverse signals, governing this coordination. Within this multi-organ framework, the liver occupies a central role in determining systemic glucose and lipid metabolism in obesity and clinically relevant metabolic pathophysiology, particularly non-alcoholic fatty liver disease (NAFLD) and fibrosis. Identification and characterization of the modes and consequences of organ cross-talk is essential to fill existing gaps in knowledge and to promote the development of therapeutic strategies to treat obesity and metabolic disease. This conference brings together experts in the novel, multidisciplinary evaluation of organ cross-talk, using innovative combinations of molecular, genetic, physiological, pharmacological and systems neuroscience approaches to: 1) Provide a unique and timely perspective, and 2) Inspire interactions directed toward basic, clinical and translational research in integrative metabolism. Finally, the joint staging of this conference in conjunction with the conference on “Bioenergetics and Metabolic Disease” will strategically leverage presentations targeting the biology of metabolism and nutrient availability in obesity with those focused on the biology of energy utilization. Taken together, this novel combination will provide a coherent, powerful and comprehensive understanding of and appreciation for the complex.
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