Bone marrow plasma cell microaggregates detected by immunohistology predict earlier relapse in patients with minimal disease after high-dose therapy for myeloma

Andrew Wei, David Westerman, Frank Feleppa, Melanit Trivett, Surender Juneja

Research output: Contribution to journalArticleOtherpeer-review

15 Citations (Scopus)

Abstract

Plasma cell microaggregates detected by CD138 immunohistology were demonstrated in 22% of patients achieving morphologic remission 3 months after high-dose therapy for myeloma. Microaggregates were predictive of earlier disease progression, indicating that immunohistology may represent a useful tool in the assessment of minimal disease in patients after high-dose therapy for myeloma.

Original languageEnglish
Pages (from-to)1147-1149
Number of pages3
JournalHaematologica
Volume90
Issue number8
Publication statusPublished - 1 Aug 2005
Externally publishedYes

Keywords

  • Immunohistology prognosis
  • MRD
  • Multiple myeloma
  • Plasma cell microaggregaies

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