Bone disease - Current knowledge and future prospects

F. Lazner, E. Wolvetang, D. Lazner, P. Hertzog

Research output: Contribution to journalArticleResearchpeer-review


The advent of genomics approaches to studying human disease have yielded a large number of genes and gene families that are involved in the process of bone formation and bone remodeling. The identification and characterization of these genes has provided significant insights into the pathogenesis of numerous human bone diseases. This review details current understanding of the role of many of these genes in bone development and disease. We review the current status of bone disease prevention/treatment modalities and describe how recent advances in our understanding of the molecules responsible for different aspects of osteoblast, osteoclast and chondrocyte function may provide novel biochemical markers and treatment strategies for bone disease.

Original languageEnglish
Pages (from-to)91-124
Number of pages34
JournalCurrent Genomics
Issue number2
Publication statusPublished - 5 Jun 2001

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