Body size and dietary risk factors for aggressive prostate cancer

a case–control study

Mikaela Pal, Allison M. Hodge, Nathan Papa, Robert J. MacInnis, Julie K. Bassett, Damien Bolton, Ian D. Davis, Jeremy Millar, Dallas R. English, John L. Hopper, Gianluca Severi, Melissa C. Southey, Roger L. Milne, Graham G. Giles

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive. Methods: A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors. Results: Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, Ptrend = 0.04), and trouser size (1.54, 1.17–2.04, Ptrend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, Ptrend = 0.05, and 0.64, 0.48–0.87, Ptrend = 0.012, respectively), but there was little evidence of an association with other dietary variables (Ptrend > 0.05). Conclusions: We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.

Original languageEnglish
Pages (from-to)1301-1312
Number of pages12
JournalCancer Causes and Control
Volume30
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Aggressive prostate cancer
  • Body mass index
  • Case–control study
  • Diet
  • Nutrition

Cite this

Pal, Mikaela ; Hodge, Allison M. ; Papa, Nathan ; MacInnis, Robert J. ; Bassett, Julie K. ; Bolton, Damien ; Davis, Ian D. ; Millar, Jeremy ; English, Dallas R. ; Hopper, John L. ; Severi, Gianluca ; Southey, Melissa C. ; Milne, Roger L. ; Giles, Graham G. / Body size and dietary risk factors for aggressive prostate cancer : a case–control study. In: Cancer Causes and Control. 2019 ; Vol. 30, No. 12. pp. 1301-1312.
@article{a70943e9d8d642ab9e543eba88f61211,
title = "Body size and dietary risk factors for aggressive prostate cancer: a case–control study",
abstract = "Purpose: Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive. Methods: A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors. Results: Positive associations with APC (odds ratio, 95{\%} confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, Ptrend = 0.04), and trouser size (1.54, 1.17–2.04, Ptrend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, Ptrend = 0.05, and 0.64, 0.48–0.87, Ptrend = 0.012, respectively), but there was little evidence of an association with other dietary variables (Ptrend > 0.05). Conclusions: We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.",
keywords = "Aggressive prostate cancer, Body mass index, Case–control study, Diet, Nutrition",
author = "Mikaela Pal and Hodge, {Allison M.} and Nathan Papa and MacInnis, {Robert J.} and Bassett, {Julie K.} and Damien Bolton and Davis, {Ian D.} and Jeremy Millar and English, {Dallas R.} and Hopper, {John L.} and Gianluca Severi and Southey, {Melissa C.} and Milne, {Roger L.} and Giles, {Graham G.}",
year = "2019",
month = "12",
doi = "10.1007/s10552-019-01234-7",
language = "English",
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Pal, M, Hodge, AM, Papa, N, MacInnis, RJ, Bassett, JK, Bolton, D, Davis, ID, Millar, J, English, DR, Hopper, JL, Severi, G, Southey, MC, Milne, RL & Giles, GG 2019, 'Body size and dietary risk factors for aggressive prostate cancer: a case–control study', Cancer Causes and Control, vol. 30, no. 12, pp. 1301-1312. https://doi.org/10.1007/s10552-019-01234-7

Body size and dietary risk factors for aggressive prostate cancer : a case–control study. / Pal, Mikaela; Hodge, Allison M.; Papa, Nathan; MacInnis, Robert J.; Bassett, Julie K.; Bolton, Damien; Davis, Ian D.; Millar, Jeremy; English, Dallas R.; Hopper, John L.; Severi, Gianluca; Southey, Melissa C.; Milne, Roger L.; Giles, Graham G.

In: Cancer Causes and Control, Vol. 30, No. 12, 12.2019, p. 1301-1312.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Body size and dietary risk factors for aggressive prostate cancer

T2 - a case–control study

AU - Pal, Mikaela

AU - Hodge, Allison M.

AU - Papa, Nathan

AU - MacInnis, Robert J.

AU - Bassett, Julie K.

AU - Bolton, Damien

AU - Davis, Ian D.

AU - Millar, Jeremy

AU - English, Dallas R.

AU - Hopper, John L.

AU - Severi, Gianluca

AU - Southey, Melissa C.

AU - Milne, Roger L.

AU - Giles, Graham G.

PY - 2019/12

Y1 - 2019/12

N2 - Purpose: Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive. Methods: A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors. Results: Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, Ptrend = 0.04), and trouser size (1.54, 1.17–2.04, Ptrend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, Ptrend = 0.05, and 0.64, 0.48–0.87, Ptrend = 0.012, respectively), but there was little evidence of an association with other dietary variables (Ptrend > 0.05). Conclusions: We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.

AB - Purpose: Diet and body size may affect the risk of aggressive prostate cancer (APC), but current evidence is inconclusive. Methods: A case–control study was conducted in men under 75 years of age recruited from urology practices in Victoria, Australia; 1,254 with APC and 818 controls for whom the presence of prostate cancer had been excluded by biopsy. Dietary intakes were assessed using a validated food frequency questionnaire. Multivariable unconditional logistic regression estimated odds ratios and confidence intervals for hypothesized risk factors, adjusting for age, family history of prostate cancer, country of birth, socioeconomic status, smoking, and other dietary factors. Results: Positive associations with APC (odds ratio, 95% confidence intervals, highest vs. lowest category or quintile) were observed for body mass index (1.34, 1.02–1.78, Ptrend = 0.04), and trouser size (1.54, 1.17–2.04, Ptrend = 0.001). Intakes of milk and all dairy products were inversely associated with APC risk (0.71, 9.53–0.96, Ptrend = 0.05, and 0.64, 0.48–0.87, Ptrend = 0.012, respectively), but there was little evidence of an association with other dietary variables (Ptrend > 0.05). Conclusions: We confirmed previous evidence for a positive association between body size and risk of APC, and suggest that consumption of dairy products, and milk more specifically, is inversely associated with risk.

KW - Aggressive prostate cancer

KW - Body mass index

KW - Case–control study

KW - Diet

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