Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Yugeesh R Lankadeva; Reetu R Singh; Lucinda M Hilliard; Karen M Moritz; Katherine M Denton

doi:10.1371/journal.pone.0047528

Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Yugeesh R Lankadeva, Reetu R Singh, Lucinda M Hilliard, Karen M Moritz, Katherine M Denton

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Abstract

Previously, we have shown that fetal uninephrectomy (uni-x) causes hypertension in female sheep by 2 years of age. Whilst the hypertension was not exacerbated by 5 years of age, these uni-x sheep had greater reductions in renal blood flow (RBF). To further explore these early indications of a decline in renal function, we investigated the renal response to a saline load (25 ml/kg/40 min) in 5-year old female uni-x and sham sheep. Basal mean arterial pressure was approximately 15 mmHg greater (P(Group)

Original language	English
Article number	e47528
Number of pages	10
Journal	PLoS ONE
Volume	7
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0047528
Publication status	Published - 2012

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10.1371/journal.pone.0047528Licence: CC BY

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AU - Singh, Reetu R

AU - Hilliard, Lucinda M

AU - Moritz, Karen M

AU - Denton, Katherine M

PY - 2012

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ER -

Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Abstract

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