Blunted sodium excretion in response to a saline load in 5 year old female sheep following fetal uninephrectomy

Yugeesh R Lankadeva, Reetu R Singh, Lucinda M Hilliard, Karen M Moritz, Katherine M Denton

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Abstract

Previously, we have shown that fetal uninephrectomy (uni-x) causes hypertension in female sheep by 2 years of age. Whilst the hypertension was not exacerbated by 5 years of age, these uni-x sheep had greater reductions in renal blood flow (RBF). To further explore these early indications of a decline in renal function, we investigated the renal response to a saline load (25 ml/kg/40 min) in 5-year old female uni-x and sham sheep. Basal mean arterial pressure was approximately 15 mmHg greater (P(Group)
Original languageEnglish
Article numbere47528
Number of pages10
JournalPLoS ONE
Volume7
Issue number10
DOIs
Publication statusPublished - 2012

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