TY - JOUR
T1 - Blood pressure trajectories during pregnancy and preterm delivery
T2 - A prospective cohort study in China
AU - Chan, Fanfan
AU - Shen, Songying
AU - Huang, Peiyuan
AU - He, Jianrong
AU - Wei, Xueling
AU - Lu, Jinhua
AU - Zhang, Lifang
AU - Xia, Xiaoyan
AU - Xia, Huimin
AU - Cheng, Kar Keung
AU - Thangaratinam, Shakila
AU - Mol, Ben Willem
AU - Qiu, Xiu
N1 - Funding Information:
The authors gratefully acknowledge all the participants from the Born in Guangzhou Cohort Study (BIGCS). Also, our gratefulness goes to the manage team, the obstetric care providers and all the staff in the BIGCS group who assisted in the implementation of this study. This research was funded by the Department of Science and Technology of Guangdong Province (grant number 2019B030316014 and 2019B020227001) and the National Natural Science Foundation of China (grant number 82173525 and 81803251). The funder had no role in study design, data collection, data analysis, data interpretation, or writing the manuscript.
Funding Information:
The authors gratefully acknowledge all the participants from the Born in Guangzhou Cohort Study (BIGCS). Also, our gratefulness goes to the manage team, the obstetric care providers and all the staff in the BIGCS group who assisted in the implementation of this study. This research was funded by the Department of Science and Technology of Guangdong Province (grant number 2019B030316014 and 2019B020227001) and the National Natural Science Foundation of China (grant number 82173525 and 81803251). The funder had no role in study design, data collection, data analysis, data interpretation, or writing the manuscript.
Publisher Copyright:
© 2022 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC.
PY - 2022/6
Y1 - 2022/6
N2 - Women's blood pressure (BP) changes throughout pregnancy. The effect of BP trajectories on preterm delivery is not clear. The authors aim to evaluate the association between maternal BP trajectories during pregnancy and preterm delivery. The authors studied pregnant women included in the Born in Guangzhou Cohort Study in China between February 2012 and June 2016. Maternal BP was measured at antenatal visits between 13 and 40 gestational weeks, and gestational age of delivery data was collected. The authors used linear mixed models to capture the BP trajectories of women with term, and spontaneous and iatrogenic preterm delivery. BP trajectories of women with various gestational lengths (34, 35, 36, 37, 38, 39, 40 weeks) were compared. Of the 17 426 women included in the analysis, 618 (3.55%) had spontaneous preterm delivery; 158 (.91%) had iatrogenic preterm delivery; and 16 650 (95.55%) women delivered at term. The BP trajectories were all J-shaped curves for different delivery types. Women with iatrogenic preterm delivery had the highest mean BP from 13 weeks till delivery, followed by those with spontaneous preterm delivery and term delivery (p <.001). Trajectory analysis stratified by maternal parity showed similar results for nulliparous and multiparous women. Excluding women with pre-eclampsia and gestational hypertension (GH) significantly attenuated the aforementioned association. Also, women with shorter gestational length tend to have higher BP trajectories during pregnancy. In conclusion, Women with spontaneous preterm delivery have a higher BP from 13 weeks till delivery than women with term delivery, while women with iatrogenic preterm delivery have the highest BP.
AB - Women's blood pressure (BP) changes throughout pregnancy. The effect of BP trajectories on preterm delivery is not clear. The authors aim to evaluate the association between maternal BP trajectories during pregnancy and preterm delivery. The authors studied pregnant women included in the Born in Guangzhou Cohort Study in China between February 2012 and June 2016. Maternal BP was measured at antenatal visits between 13 and 40 gestational weeks, and gestational age of delivery data was collected. The authors used linear mixed models to capture the BP trajectories of women with term, and spontaneous and iatrogenic preterm delivery. BP trajectories of women with various gestational lengths (34, 35, 36, 37, 38, 39, 40 weeks) were compared. Of the 17 426 women included in the analysis, 618 (3.55%) had spontaneous preterm delivery; 158 (.91%) had iatrogenic preterm delivery; and 16 650 (95.55%) women delivered at term. The BP trajectories were all J-shaped curves for different delivery types. Women with iatrogenic preterm delivery had the highest mean BP from 13 weeks till delivery, followed by those with spontaneous preterm delivery and term delivery (p <.001). Trajectory analysis stratified by maternal parity showed similar results for nulliparous and multiparous women. Excluding women with pre-eclampsia and gestational hypertension (GH) significantly attenuated the aforementioned association. Also, women with shorter gestational length tend to have higher BP trajectories during pregnancy. In conclusion, Women with spontaneous preterm delivery have a higher BP from 13 weeks till delivery than women with term delivery, while women with iatrogenic preterm delivery have the highest BP.
KW - blood pressure
KW - iatrogenic preterm delivery
KW - pregnancy
KW - preterm delivery
KW - spontaneous preterm delivery
UR - https://www.scopus.com/pages/publications/85131046875
U2 - 10.1111/jch.14494
DO - 10.1111/jch.14494
M3 - Article
C2 - 35651280
AN - SCOPUS:85131046875
SN - 1524-6175
VL - 24
SP - 770
EP - 778
JO - Journal of Clinical Hypertension
JF - Journal of Clinical Hypertension
IS - 6
ER -
SDG 3 Good Health and Well-being