Blood cell diffusion visualization using multiple hydrodynamic flow focusing

F. J. Tovar-Lopez; G. Rosengarten; M. Nasabi; V. Sivan; S. P. Jackson; W. S. Nesbitt; A. Mitchell

Blood cell diffusion visualization using multiple hydrodynamic flow focusing

F. J. Tovar-Lopez, G. Rosengarten, M. Nasabi, V. Sivan, S. P. Jackson, W. S. Nesbitt, A. Mitchell

Australian Centre for Blood Diseases

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

1 Citation (Scopus)

Abstract

This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways¹. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.

Original language	English
Title of host publication	15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages	45-47
Number of pages	3
Volume	1
Publication status	Published - 1 Dec 2011
Event	International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2011) - Seattle, United States of America Duration: 2 Oct 2011 → 6 Oct 2011 Conference number: 15th

Conference

Conference	International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2011)
Abbreviated title	MicroTAS 2011
Country/Territory	United States of America
City	Seattle
Period	2/10/11 → 6/10/11

Keywords

Blood cell diffusion
Flow focusing
Flow sheaths
Mass transport
Thrombosis

Cite this

@inproceedings{dbf708dfbd4f47cd94bad2ff9b5941a9,

title = "Blood cell diffusion visualization using multiple hydrodynamic flow focusing",

abstract = "This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.",

keywords = "Blood cell diffusion, Flow focusing, Flow sheaths, Mass transport, Thrombosis",

author = "Tovar-Lopez, {F. J.} and G. Rosengarten and M. Nasabi and V. Sivan and Jackson, {S. P.} and Nesbitt, {W. S.} and A. Mitchell",

year = "2011",

month = dec,

day = "1",

language = "English",

isbn = "9781618395955",

volume = "1",

pages = "45--47",

booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",

note = "International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2011), MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",

}

Tovar-Lopez, FJ, Rosengarten, G, Nasabi, M, Sivan, V, Jackson, SP, Nesbitt, WS & Mitchell, A 2011, Blood cell diffusion visualization using multiple hydrodynamic flow focusing. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 1, pp. 45-47, International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2011), Seattle, Washington, United States of America, 2/10/11.

Blood cell diffusion visualization using multiple hydrodynamic flow focusing. / Tovar-Lopez, F. J.; Rosengarten, G.; Nasabi, M. et al.
15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. p. 45-47.

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

TY - GEN

T1 - Blood cell diffusion visualization using multiple hydrodynamic flow focusing

AU - Tovar-Lopez, F. J.

AU - Rosengarten, G.

AU - Nasabi, M.

AU - Sivan, V.

AU - Jackson, S. P.

AU - Nesbitt, W. S.

AU - Mitchell, A.

N1 - Conference code: 15th

PY - 2011/12/1

Y1 - 2011/12/1

N2 - This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.

AB - This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.

KW - Blood cell diffusion

KW - Flow focusing

KW - Flow sheaths

KW - Mass transport

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=84883811329&partnerID=8YFLogxK

M3 - Conference Paper

AN - SCOPUS:84883811329

SN - 9781618395955

VL - 1

SP - 45

EP - 47

BT - 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011

T2 - International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2011)

Y2 - 2 October 2011 through 6 October 2011

ER -

Blood cell diffusion visualization using multiple hydrodynamic flow focusing

Abstract

Conference

Keywords

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