Blood cell diffusion visualization using multiple hydrodynamic flow focusing

F. J. Tovar-Lopez, G. Rosengarten, M. Nasabi, V. Sivan, S. P. Jackson, W. S. Nesbitt, A. Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

1 Citation (Scopus)

Abstract

This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.

Original languageEnglish
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages45-47
Number of pages3
Volume1
Publication statusPublished - 1 Dec 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States of America
Duration: 2 Oct 20116 Oct 2011

Conference

Conference15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States of America
CitySeattle, WA
Period2/10/116/10/11

Keywords

  • Blood cell diffusion
  • Flow focusing
  • Flow sheaths
  • Mass transport
  • Thrombosis

Cite this

Tovar-Lopez, F. J., Rosengarten, G., Nasabi, M., Sivan, V., Jackson, S. P., Nesbitt, W. S., & Mitchell, A. (2011). Blood cell diffusion visualization using multiple hydrodynamic flow focusing. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (Vol. 1, pp. 45-47)
Tovar-Lopez, F. J. ; Rosengarten, G. ; Nasabi, M. ; Sivan, V. ; Jackson, S. P. ; Nesbitt, W. S. ; Mitchell, A. / Blood cell diffusion visualization using multiple hydrodynamic flow focusing. 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. pp. 45-47
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abstract = "This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.",
keywords = "Blood cell diffusion, Flow focusing, Flow sheaths, Mass transport, Thrombosis",
author = "Tovar-Lopez, {F. J.} and G. Rosengarten and M. Nasabi and V. Sivan and Jackson, {S. P.} and Nesbitt, {W. S.} and A. Mitchell",
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Tovar-Lopez, FJ, Rosengarten, G, Nasabi, M, Sivan, V, Jackson, SP, Nesbitt, WS & Mitchell, A 2011, Blood cell diffusion visualization using multiple hydrodynamic flow focusing. in 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. vol. 1, pp. 45-47, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, Seattle, WA, United States of America, 2/10/11.

Blood cell diffusion visualization using multiple hydrodynamic flow focusing. / Tovar-Lopez, F. J.; Rosengarten, G.; Nasabi, M.; Sivan, V.; Jackson, S. P.; Nesbitt, W. S.; Mitchell, A.

15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1 2011. p. 45-47.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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T1 - Blood cell diffusion visualization using multiple hydrodynamic flow focusing

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AU - Nesbitt, W. S.

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AB - This paper reports on the development of a microfluidic platform to study mass transport mechanisms of blood cells and fluid visualization of fluid streamlines on micro-contractions. Micro fabricated contractions can mimic the haemodynamics of pathological vessels to observe thrombi formation independent of chemical pathways1. Under these conditions thrombus formation is affected by a number of variables including blood cell stress history, cellular diffusion and cellular interaction. By using a multiple hydrodynamic flow focusing approach, these variables can be explored systematically. This platform will help to study the role of mass transport phenomena in platelet thrombosis at microscale.

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Tovar-Lopez FJ, Rosengarten G, Nasabi M, Sivan V, Jackson SP, Nesbitt WS et al. Blood cell diffusion visualization using multiple hydrodynamic flow focusing. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1. 2011. p. 45-47