Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Sahar G Eid; Niamh Mangan; Paul John Hertzog; Johnson Mak

doi:10.1038/cti.2015.23

Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Sahar G Eid, Niamh Mangan, Paul John Hertzog, Johnson Mak

Research output: Contribution to journal › Review Article › Research › peer-review

4 Citations (Scopus)

Abstract

The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides’ clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

Original language	English
Article number	e43
Number of pages	9
Journal	Clinical & Translational Immunology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1038/cti.2015.23
Publication status	Published - 1 Oct 2015
Externally published	Yes

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title = "Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses",

abstract = "The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides{\textquoteright} clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.",

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Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Abstract

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