Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Sahar G Eid, Niamh Mangan, Paul John Hertzog, Johnson Mak

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
Original languageEnglish
Article numbere43
Number of pages9
JournalClinical and Translational Immunology
Volume4
Issue number10
DOIs
Publication statusPublished - 2015

Cite this

@article{6388a19b4c894fa599ba126751d64cfb,
title = "Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses",
abstract = "The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.",
author = "Eid, {Sahar G} and Niamh Mangan and Hertzog, {Paul John} and Johnson Mak",
year = "2015",
doi = "10.1038/cti.2015.23",
language = "English",
volume = "4",
journal = "Clinical and Translational Immunology",
issn = "2050-0068",
publisher = "Nature Publishing Group",
number = "10",

}

Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses. / Eid, Sahar G; Mangan, Niamh; Hertzog, Paul John; Mak, Johnson.

In: Clinical and Translational Immunology, Vol. 4, No. 10, e43, 2015.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

AU - Eid, Sahar G

AU - Mangan, Niamh

AU - Hertzog, Paul John

AU - Mak, Johnson

PY - 2015

Y1 - 2015

N2 - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

AB - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673443/pdf/cti201523a.pdf

U2 - 10.1038/cti.2015.23

DO - 10.1038/cti.2015.23

M3 - Article

VL - 4

JO - Clinical and Translational Immunology

JF - Clinical and Translational Immunology

SN - 2050-0068

IS - 10

M1 - e43

ER -