Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Sahar G Eid; Niamh Mangan; Paul John Hertzog; Johnson Mak

doi:10.1038/cti.2015.23

Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

Sahar G Eid, Niamh Mangan, Paul John Hertzog, Johnson Mak

Hudson Institute - Centre for Innate Immunity and Infectious Disease

Research output: Contribution to journal › Article › Research › peer-review

Abstract

The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

Original language	English
Article number	e43
Number of pages	9
Journal	Clinical & Translational Immunology
Volume	4
Issue number	10
DOIs	https://doi.org/10.1038/cti.2015.23
Publication status	Published - 2015

Access to Document

10.1038/cti.2015.23Licence: CC BY-NC-SA

3567078-oaFinal published version, 923 KBLicence: CC BY-NC-SA

RM sElocation

Cite this

@article{6388a19b4c894fa599ba126751d64cfb,

title = "Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses",

abstract = "The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.",

author = "Eid, {Sahar G} and Niamh Mangan and Hertzog, {Paul John} and Johnson Mak",

year = "2015",

doi = "10.1038/cti.2015.23",

language = "English",

volume = "4",

journal = "Clinical & Translational Immunology",

issn = "2050-0068",

publisher = "John Wiley & Sons",

number = "10",

}

TY - JOUR

T1 - Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses

AU - Eid, Sahar G

AU - Mangan, Niamh

AU - Hertzog, Paul John

AU - Mak, Johnson

PY - 2015

Y1 - 2015

N2 - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

AB - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673443/pdf/cti201523a.pdf

U2 - 10.1038/cti.2015.23

DO - 10.1038/cti.2015.23

M3 - Article

VL - 4

JO - Clinical & Translational Immunology

JF - Clinical & Translational Immunology

SN - 2050-0068

IS - 10

M1 - e43

ER -