Abstract
| Original language | English |
|---|---|
| Article number | e43 |
| Number of pages | 9 |
| Journal | Clinical and Translational Immunology |
| Volume | 4 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2015 |
Cite this
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Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses. / Eid, Sahar G; Mangan, Niamh; Hertzog, Paul John; Mak, Johnson.
In: Clinical and Translational Immunology, Vol. 4, No. 10, e43, 2015.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Blocking HIV-1 transmission in the female reproductive tract: from microbicide development to exploring local antiviral responses
AU - Eid, Sahar G
AU - Mangan, Niamh
AU - Hertzog, Paul John
AU - Mak, Johnson
PY - 2015
Y1 - 2015
N2 - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
AB - The majority of new HIV-1 infections are transmitted sexually by penetrating the mucosal barrier to infect target cells. The development of microbicides to restrain heterosexual HIV-1 transmission in the past two decades has proven to be a challenging endeavor. Therefore, better understanding of the tissue environment in the female reproductive tract may assist in the development of the next generation of microbicides to prevent HIV-1 transmission. In this review, we highlight the important factors involved in the heterosexual transmission of HIV-1, provide an update on microbicides clinical trials, and discuss how different delivery platforms and local immunity may empower the development of next generation of microbicide to block HIV-1 transmission in the female reproductive tract.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673443/pdf/cti201523a.pdf
U2 - 10.1038/cti.2015.23
DO - 10.1038/cti.2015.23
M3 - Article
VL - 4
JO - Clinical and Translational Immunology
JF - Clinical and Translational Immunology
SN - 2050-0068
IS - 10
M1 - e43
ER -