BK virus associated nephropathy, a cause of early renal allograft dysfunction: a single centre study

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia. Method A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glomerular filtration rate (eGFR) was compared at baseline, at BKVN diagnosis and 3 and 12 months postdiagnosis. Result Of the 317 de novo renal transplants recipients in the study period, 20 (6.3 ) developed BKVN. The mean age was 54.8 +/- 13.1 years and 13 (65 ) were male. The mean time from transplant to BKVN was 8.7 +/- 6.7 months with 17 (85 ) diagnosed within 12 months. Four recipients each were diagnosed BKVN on 3 and 12 month surveillance biopsy. Six (30 ) had normal eGFR at diagnosis. Mean eGFR at diagnosis was 38.8 +/- 19.2 ml/min/1.73 m2, which was significantly lower (p <0.01) than that at baseline (50.3 +/- 16.4 ml/min/1.73 m2). eGFR improved numerically at 3 and 12 months post-diagnosis, however the difference was not significant. One patient had graft failure, 19 months after diagnosis. Conclusion BKVN generally occurs in first post-transplant year and is an important cause of early graft dysfunction. Surveillance biopsy helps in detecting subclinical BKVN.
Original languageEnglish
Pages (from-to)140 - 145
Number of pages6
JournalKathmandu University Medical Journal
Volume13
Issue number50
Publication statusPublished - 2015

Cite this

@article{50e126b39ca347c1909817075ea782e7,
title = "BK virus associated nephropathy, a cause of early renal allograft dysfunction: a single centre study",
abstract = "Background BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia. Method A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glomerular filtration rate (eGFR) was compared at baseline, at BKVN diagnosis and 3 and 12 months postdiagnosis. Result Of the 317 de novo renal transplants recipients in the study period, 20 (6.3 ) developed BKVN. The mean age was 54.8 +/- 13.1 years and 13 (65 ) were male. The mean time from transplant to BKVN was 8.7 +/- 6.7 months with 17 (85 ) diagnosed within 12 months. Four recipients each were diagnosed BKVN on 3 and 12 month surveillance biopsy. Six (30 ) had normal eGFR at diagnosis. Mean eGFR at diagnosis was 38.8 +/- 19.2 ml/min/1.73 m2, which was significantly lower (p <0.01) than that at baseline (50.3 +/- 16.4 ml/min/1.73 m2). eGFR improved numerically at 3 and 12 months post-diagnosis, however the difference was not significant. One patient had graft failure, 19 months after diagnosis. Conclusion BKVN generally occurs in first post-transplant year and is an important cause of early graft dysfunction. Surveillance biopsy helps in detecting subclinical BKVN.",
author = "Shailendra Shrestha and Kerr, {Peter G} and John Kanellis and Polkinghorne, {Kevan R} and Brown, {Fiona G} and Yii, {Ming Kon} and William Mulley",
year = "2015",
language = "English",
volume = "13",
pages = "140 -- 145",
journal = "Kathmandu University Medical Journal",
issn = "1812-2027",
publisher = "Kathmandu University",
number = "50",

}

BK virus associated nephropathy, a cause of early renal allograft dysfunction: a single centre study. / Shrestha, Shailendra; Kerr, Peter G; Kanellis, John; Polkinghorne, Kevan R; Brown, Fiona G; Yii, Ming Kon; Mulley, William.

In: Kathmandu University Medical Journal, Vol. 13, No. 50, 2015, p. 140 - 145.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - BK virus associated nephropathy, a cause of early renal allograft dysfunction: a single centre study

AU - Shrestha, Shailendra

AU - Kerr, Peter G

AU - Kanellis, John

AU - Polkinghorne, Kevan R

AU - Brown, Fiona G

AU - Yii, Ming Kon

AU - Mulley, William

PY - 2015

Y1 - 2015

N2 - Background BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia. Method A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glomerular filtration rate (eGFR) was compared at baseline, at BKVN diagnosis and 3 and 12 months postdiagnosis. Result Of the 317 de novo renal transplants recipients in the study period, 20 (6.3 ) developed BKVN. The mean age was 54.8 +/- 13.1 years and 13 (65 ) were male. The mean time from transplant to BKVN was 8.7 +/- 6.7 months with 17 (85 ) diagnosed within 12 months. Four recipients each were diagnosed BKVN on 3 and 12 month surveillance biopsy. Six (30 ) had normal eGFR at diagnosis. Mean eGFR at diagnosis was 38.8 +/- 19.2 ml/min/1.73 m2, which was significantly lower (p <0.01) than that at baseline (50.3 +/- 16.4 ml/min/1.73 m2). eGFR improved numerically at 3 and 12 months post-diagnosis, however the difference was not significant. One patient had graft failure, 19 months after diagnosis. Conclusion BKVN generally occurs in first post-transplant year and is an important cause of early graft dysfunction. Surveillance biopsy helps in detecting subclinical BKVN.

AB - Background BK virus associated nephropathy (BKVN) is an important cause of early graft dysfunction in renal transplant recipients. The present study was carried out to determine the burden of BKVN in a single renal transplant centre in Australia. Method A retrospective analysis of de novo renal transplant recipients from 2010 to 2013 was performed to identify biopsy proven BKVN. Estimated glomerular filtration rate (eGFR) was compared at baseline, at BKVN diagnosis and 3 and 12 months postdiagnosis. Result Of the 317 de novo renal transplants recipients in the study period, 20 (6.3 ) developed BKVN. The mean age was 54.8 +/- 13.1 years and 13 (65 ) were male. The mean time from transplant to BKVN was 8.7 +/- 6.7 months with 17 (85 ) diagnosed within 12 months. Four recipients each were diagnosed BKVN on 3 and 12 month surveillance biopsy. Six (30 ) had normal eGFR at diagnosis. Mean eGFR at diagnosis was 38.8 +/- 19.2 ml/min/1.73 m2, which was significantly lower (p <0.01) than that at baseline (50.3 +/- 16.4 ml/min/1.73 m2). eGFR improved numerically at 3 and 12 months post-diagnosis, however the difference was not significant. One patient had graft failure, 19 months after diagnosis. Conclusion BKVN generally occurs in first post-transplant year and is an important cause of early graft dysfunction. Surveillance biopsy helps in detecting subclinical BKVN.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26643831

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VL - 13

SP - 140

EP - 145

JO - Kathmandu University Medical Journal

JF - Kathmandu University Medical Journal

SN - 1812-2027

IS - 50

ER -