Bisucaberin biosynthesis: An adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine

Nadia Kadi, Lijiang Song, Gregory L. Challis

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)


The bisucaberin biosynthetic gene cluster has been identified in Vibrio salmonicida and a domain from within the BibC multienzyme encoded by the cluster has been shown to catalyse ATP-dependent dimerisation and macrocyclisation of N-hydroxy-N-succinylcadaverine to form bisucaberin.

Original languageEnglish
Pages (from-to)5119-5121
Number of pages3
JournalChemical Communications
Issue number41
Publication statusPublished - 4 Nov 2008
Externally publishedYes

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