The formation of bismuth(III) complexes of carboxylates and benzoates derived from the 1 : 3 reaction of BiPh3 with the common non-steroidal anti-inflammatory drugs ( NSAIDs) ketoprofen, naproxen, ibuprofen, mefenamic acid, diflunisal, 5-chlorosalicylic acid, fenbufen, sulindac, tolfenamic acid and flufenamic acid, has been achieved using both solvent-free and solvent-mediated methods. The thermochemical profiles of the solvent-free reactions were studied using DSC-TGA. All reactions produced the tris-substituted complexes of general formula [BiL3](n), with the complexes derived from ketoprofen and sulindac having an additional single bismuth bound H2O molecule in the inner coordination sphere. The complexes are stable in air over a period of six months, do not undergo significant decomposition when suspended overnight in water, but decompose in 1 M HCl solution to release the free acid form of the NSAID. All ten complexes show excellent in vitro activity against Helicobacter pylori with MIC values of >= 6.25 mu g mL(-1).
Andrews, P. C., Ferrero, R. L., Junk, P. C., Kumar, I., Luu, Q., Nguyen, K., & Taylor, J. W. (2010). Bismuth(III) complexes derived from non-steroidal anti-inflammatory drugs and their activity against Helicobacter pylori. Dalton Transactions, 39(11), 2861 - 2868. https://doi.org/10.1039/c000164c