Bismuth Phosphinates in Bi-Nanocellulose Composites and their Efficacy towards Multi-Drug Resistant Bacteria

Melissa V Werrett, Megan E Herdman, Rajini Brammananth, Uthpala Garusinghe, Warren Batchelor, Paul Crellin, Ross Coppel, Philip C. Andrews

Research output: Contribution to journalArticleResearchpeer-review

Abstract

A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R1R2)2] (R1=R2=Ph; R1=R2=p-OMePh; R1=R2=m-NO2Ph; R1=Ph, R2=H; R1=R2=Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43wt% into nanocellulose produces a 10mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph2)2] loaded at 0.34wt% produces an 18mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.

Original languageEnglish
Pages (from-to)12938-12949
Number of pages12
JournalChemistry - A European Journal
Volume24
Issue number49
DOIs
Publication statusPublished - 2018

Keywords

  • Antibacterial
  • Bismuth
  • Materials
  • Nanocellulose
  • Phosphinate

Cite this

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title = "Bismuth Phosphinates in Bi-Nanocellulose Composites and their Efficacy towards Multi-Drug Resistant Bacteria",
abstract = "A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R1R2)2] (R1=R2=Ph; R1=R2=p-OMePh; R1=R2=m-NO2Ph; R1=Ph, R2=H; R1=R2=Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43wt{\%} into nanocellulose produces a 10mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph2)2] loaded at 0.34wt{\%} produces an 18mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.",
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Bismuth Phosphinates in Bi-Nanocellulose Composites and their Efficacy towards Multi-Drug Resistant Bacteria. / Werrett, Melissa V; Herdman, Megan E; Brammananth, Rajini; Garusinghe, Uthpala; Batchelor, Warren; Crellin, Paul; Coppel, Ross; Andrews, Philip C.

In: Chemistry - A European Journal, Vol. 24, No. 49, 2018, p. 12938-12949.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Bismuth Phosphinates in Bi-Nanocellulose Composites and their Efficacy towards Multi-Drug Resistant Bacteria

AU - Werrett, Melissa V

AU - Herdman, Megan E

AU - Brammananth, Rajini

AU - Garusinghe, Uthpala

AU - Batchelor, Warren

AU - Crellin, Paul

AU - Coppel, Ross

AU - Andrews, Philip C.

PY - 2018

Y1 - 2018

N2 - A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R1R2)2] (R1=R2=Ph; R1=R2=p-OMePh; R1=R2=m-NO2Ph; R1=Ph, R2=H; R1=R2=Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43wt% into nanocellulose produces a 10mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph2)2] loaded at 0.34wt% produces an 18mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.

AB - A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R1R2)2] (R1=R2=Ph; R1=R2=p-OMePh; R1=R2=m-NO2Ph; R1=Ph, R2=H; R1=R2=Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43wt% into nanocellulose produces a 10mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph2)2] loaded at 0.34wt% produces an 18mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.

KW - Antibacterial

KW - Bismuth

KW - Materials

KW - Nanocellulose

KW - Phosphinate

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U2 - 10.1002/chem.201801803

DO - 10.1002/chem.201801803

M3 - Article

VL - 24

SP - 12938

EP - 12949

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 1521-3765

IS - 49

ER -