Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Michelle T. Fodero-Tavoletti; Victor L. Villemagne; Brett M. Paterson; Anthony R. White; Qiao Xin Li; James Camakaris; Graeme O'keefe; Roberto Cappai; Kevin J. Barnham; Paul S. Donnelly

doi:10.3233/JAD-2010-1359

Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease

Michelle T. Fodero-Tavoletti, Victor L. Villemagne, Brett M. Paterson, Anthony R. White, Qiao Xin Li, James Camakaris, Graeme O'keefe, Roberto Cappai, Kevin J. Barnham, Paul S. Donnelly

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

Abstract

A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.

Original language	English
Pages (from-to)	49-55
Number of pages	7
Journal	Journal of Alzheimer's Disease
Volume	20
Issue number	1
DOIs	https://doi.org/10.3233/JAD-2010-1359
Publication status	Published - 2010
Externally published	Yes

Keywords

Alzheimer's disease
copper homeostasis
copper radiopharmaceuticals
diagnostic imaging
positron emission tomography (PET)

Access to Document

10.3233/JAD-2010-1359

Link to publication in Scopus

Cite this

Fodero-Tavoletti, Michelle T. ; Villemagne, Victor L. ; Paterson, Brett M. ; White, Anthony R. ; Li, Qiao Xin ; Camakaris, James ; O'keefe, Graeme ; Cappai, Roberto ; Barnham, Kevin J. ; Donnelly, Paul S. / Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. In: Journal of Alzheimer's Disease. 2010 ; Vol. 20, No. 1. pp. 49-55.

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abstract = "A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.",

keywords = "Alzheimer's disease, copper homeostasis, copper radiopharmaceuticals, diagnostic imaging, positron emission tomography (PET)",

author = "Fodero-Tavoletti, {Michelle T.} and Villemagne, {Victor L.} and Paterson, {Brett M.} and White, {Anthony R.} and Li, {Qiao Xin} and James Camakaris and Graeme O'keefe and Roberto Cappai and Barnham, {Kevin J.} and Donnelly, {Paul S.}",

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Bis (thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease. / Fodero-Tavoletti, Michelle T.; Villemagne, Victor L.; Paterson, Brett M.; White, Anthony R.; Li, Qiao Xin; Camakaris, James; O'keefe, Graeme; Cappai, Roberto; Barnham, Kevin J.; Donnelly, Paul S.

In: Journal of Alzheimer's Disease, Vol. 20, No. 1, 2010, p. 49-55.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Villemagne, Victor L.

AU - Paterson, Brett M.

AU - White, Anthony R.

AU - Li, Qiao Xin

AU - Camakaris, James

AU - O'keefe, Graeme

AU - Cappai, Roberto

AU - Barnham, Kevin J.

AU - Donnelly, Paul S.

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