Bioorthogonal hydrogels by thiol–halide click crosslinking with fast gelation time and tunable stability in aqueous media

Vinh X. Truong; Ilze Donderwinkel; Jessica E. Frith

doi:10.1002/pola.29267

Bioorthogonal hydrogels by thiol–halide click crosslinking with fast gelation time and tunable stability in aqueous media

Vinh X. Truong, Ilze Donderwinkel, Jessica E. Frith

Materials Science & Engineering

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Abstract

Thiol‐halide click reaction is utilized in polymer crosslinking to form hydrogels with tailored rate of disintegration suitable. The crosslinking process is bioorthogonal, which allows for encapsulation of living cells for three‐dimensional cell culture study.

Original language	English
Pages (from-to)	1872-1876
Number of pages	5
Journal	Journal of Polymer Science, Part A: Polymer Chemistry
Volume	57
Issue number	18
DOIs	https://doi.org/10.1002/pola.29267
Publication status	Published - 15 Sep 2019

Keywords

biocompatibility
bioorthogonal click
cell-laden hydrogels
degradation
fibroblast
mesenchymal stem cell
thiol–bromo click
thiol–iodo click

Access to Document

10.1002/pola.29267

254961560-oaFinal published version, 1.1 MB

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Cite this

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title = "Bioorthogonal hydrogels by thiol–halide click crosslinking with fast gelation time and tunable stability in aqueous media",

abstract = "Thiol‐halide click reaction is utilized in polymer crosslinking to form hydrogels with tailored rate of disintegration suitable. The crosslinking process is bioorthogonal, which allows for encapsulation of living cells for three‐dimensional cell culture study.",

keywords = "biocompatibility, bioorthogonal click, cell-laden hydrogels, degradation, fibroblast, mesenchymal stem cell, thiol–bromo click, thiol–iodo click",

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AU - Truong, Vinh X.

AU - Donderwinkel, Ilze

AU - Frith, Jessica E.

PY - 2019/9/15

Y1 - 2019/9/15

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AB - Thiol‐halide click reaction is utilized in polymer crosslinking to form hydrogels with tailored rate of disintegration suitable. The crosslinking process is bioorthogonal, which allows for encapsulation of living cells for three‐dimensional cell culture study.

KW - biocompatibility

KW - bioorthogonal click

KW - cell-laden hydrogels

KW - degradation

KW - fibroblast

KW - mesenchymal stem cell

KW - thiol–bromo click

KW - thiol–iodo click

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JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

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