Biomimetic peptide-gated nanoporous membrane for on-demand molecule transport

Kai Xiao, Kai Wu, Lu Chen, Xiang Yu Kong, Yuqi Zhang, Liping Wen, Lei Jiang

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

The controllable molecule transport is crucial to realize many highly valuable applications both in vivo and in vitro. Nanoporous membranes, with nanoscopic pores, high porosity, uniform pore dimensions, and controllable surface chemical properties, hold tremendous potential to achieve this function. Herein, we report a nano-gating system for on-demand molecule transport based on a peptide-gated nanoporous membrane. Acting as gatekeeper, the peptides introduced to the nanoporous membrane provide an opportunity to realize on-demand on–off states via reversible conformational switching of the peptides. This nano-gating system offers sustained release and can be used as a sophisticated molecule transport platform for localized drug delivery with a feedback function.

Original languageEnglish
Pages (from-to)151-155
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number1
DOIs
Publication statusPublished - 2 Jan 2018
Externally publishedYes

Keywords

  • molecule transport
  • nano-gating
  • nanochannel
  • peptide
  • porous membranes

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