TY - JOUR
T1 - Biomedical applications of metallic nanoparticles in cancer
T2 - Current status and future perspectives
AU - Khursheed, Rubiya
AU - Dua, Kamal
AU - Vishwas, Sukriti
AU - Gulati, Monica
AU - Jha, Niraj Kumar
AU - Aldhafeeri, Ghalib Mohammed
AU - Alanazi, Fayez Ghadeer
AU - Goh, Bey Hing
AU - Gupta, Gaurav
AU - Paudel, Keshav Raj
AU - Hansbro, Philip M.
AU - Chellappan, Dinesh Kumar
AU - Singh, Sachin Kumar
N1 - Funding Information:
The authors would like to acknowledge the support provided by the School of Pharmaceutical Sciences, Lovely Professional University, India; the Graduate School of Health, University of Technology Sydney, Australia; and the Australian Research Centre in Complementary and Integrative Medicine.
Funding Information:
PMH is funded by a Fellowship and grants from the National Health and Medical Research Council (NHMRC) of Australia ( 1175134 ), by UTS and the Cancer Council of NSW ( #1157073 ).
Publisher Copyright:
© 2022
PY - 2022/6
Y1 - 2022/6
N2 - The current advancements in nanotechnology are as an outcome of the development of engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot of attention in biomedical field due to their significant inert nature, and nanoscale structures, with size similar to many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle characteristics such as size, shape, environment, aspect ratio, ease of synthesis and functionalization properties have led to numerous applications in various fields of biomedicine. These include targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, as well as the modulation of two or three applications. The current article also discusses about the various properties of metallic nanoparticles and their applications in cancer imaging and therapeutics. The associated bottlenecks related to their clinical translation are also discussed.
AB - The current advancements in nanotechnology are as an outcome of the development of engineered nanoparticles. Various metallic nanoparticles have been extensively explored for various biomedical applications. They attract lot of attention in biomedical field due to their significant inert nature, and nanoscale structures, with size similar to many biological molecules. Their intrinsic characteristics which include electronic, optical, physicochemical and, surface plasmon resonance, that can be changed by altering certain particle characteristics such as size, shape, environment, aspect ratio, ease of synthesis and functionalization properties have led to numerous applications in various fields of biomedicine. These include targeted drug delivery, sensing, photothermal and photodynamic therapy, imaging, as well as the modulation of two or three applications. The current article also discusses about the various properties of metallic nanoparticles and their applications in cancer imaging and therapeutics. The associated bottlenecks related to their clinical translation are also discussed.
KW - Cancer
KW - Drug delivery
KW - Metallic nanoparticles
KW - Nanotechnology
UR - http://www.scopus.com/inward/record.url?scp=85128267023&partnerID=8YFLogxK
U2 - 10.1016/j.biopha.2022.112951
DO - 10.1016/j.biopha.2022.112951
M3 - Review Article
AN - SCOPUS:85128267023
SN - 0753-3322
VL - 150
JO - Biomedicine & Pharmacotherapy
JF - Biomedicine & Pharmacotherapy
M1 - 112951
ER -
