Biomaterial Strategies for Restorative Therapies in Parkinson's Disease

Samaneh Mirzaei, Ketav Kulkarni, Kun Zhou, Peter J. Crack, Marie Isabel Aguilar, David I. Finkelstein, John S. Forsythe

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a progressive neurological disorder, in which dopaminergic midbrain neurons degenerate, leading to dopamine depletion that is associated with neuronal death. In this Review, we initially describe the pathogenesis of PD and established therapies that unfortunately only delay progression of the disease. With a rapidly escalating incidence in PD, there is an urgent need to develop new therapies that not only halt progression but even reverse degeneration. Biomaterials are playing critical roles in these new therapies which include controlled and site-specific delivery of neurotrophins, increased engraftment of implanted neural stem cells, and redirection of endogenous stem cell populations away from their niche to encourage reparative mechanisms. This Review will therefore cover important design features of biomaterials used in regenerative medicine and tissue engineering strategies targeted at PD.

Original languageEnglish
Pages (from-to)4224-4235
Number of pages12
JournalACS Chemical Neuroscience
Volume12
Issue number22
DOIs
Publication statusPublished - 17 Nov 2021

Keywords

  • Biomaterials
  • Cell-based therapy
  • Drug/gene/trophic delivery
  • Endogenous neural stem cells
  • Hydrogels
  • Parkinson's disease

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