Biomaterial science meets computational biology

Dietmar W. Hutmacher, J. Paige Little, Graeme J. Pettet, Daniela Loessner

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.

Original languageEnglish
Article number185
Number of pages3
JournalJournal of Materials Science: Materials in Medicine
Volume26
Issue number5
DOIs
Publication statusPublished - May 2015
Externally publishedYes

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