TY - JOUR
T1 - Biomaterial science meets computational biology
AU - Hutmacher, Dietmar W.
AU - Little, J. Paige
AU - Pettet, Graeme J.
AU - Loessner, Daniela
PY - 2015/5
Y1 - 2015/5
N2 - There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.
AB - There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.
UR - http://www.scopus.com/inward/record.url?scp=84928665131&partnerID=8YFLogxK
U2 - 10.1007/s10856-015-5518-z
DO - 10.1007/s10856-015-5518-z
M3 - Article
C2 - 25893394
AN - SCOPUS:84928665131
VL - 26
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 5
M1 - 185
ER -