Abstract
There is a pressing need for a predictive tool capable of revealing a holistic understanding of fundamental elements in the normal and pathological cell physiology of organoids in order to decipher the mechanoresponse of cells. Therefore, the integration of a systems bioengineering approach into a validated mathematical model is necessary to develop a new simulation tool. This tool can only be innovative by combining biomaterials science with computational biology. Systems-level and multi-scale experimental data are incorporated into a single framework, thus representing both single cells and collective cell behaviour. Such a computational platform needs to be validated in order to discover key mechano-biological factors associated with cell–cell and cell–niche interactions.
| Original language | English |
|---|---|
| Article number | 185 |
| Number of pages | 3 |
| Journal | Journal of Materials Science: Materials in Medicine |
| Volume | 26 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2015 |
| Externally published | Yes |