Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection

Gregor Lichtfuss, Jennifer Hoy, Reena Rajasuriar, Marit Kramski, Suzanne Crowe, Sharon Lewin

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

Here we review biomarkers of T-cell activation (CD69, -25 and -38, HLA-DR, and soluble CD26 and -30); generalized immune activation (C-reactive protein, IL-6 and D-dimer); microbial translocation (lipopolysaccharide, 16S rDNA, lipopolysaccharide-binding protein and soluble CD14); and immune dysfunction of specific cellular subsets (T cells, natural killer cells and monocytes) in HIV-infected patients on cART and their relationship to adverse clinical outcomes including impaired CD4 T-cell recovery, as well as non-AIDS clinical events, such as cardiovascular disease
Original languageEnglish
Pages (from-to)171 - 186
Number of pages16
JournalBiomarkers in Medicine
Volume5
Issue number2
Publication statusPublished - 2011

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