TY - JOUR
T1 - Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection
AU - Lichtfuss, Gregor
AU - Hoy, Jennifer
AU - Rajasuriar, Reena
AU - Kramski, Marit
AU - Crowe, Suzanne
AU - Lewin, Sharon
PY - 2011
Y1 - 2011
N2 - Here we review biomarkers of T-cell activation (CD69, -25 and -38, HLA-DR, and soluble CD26 and -30); generalized immune activation (C-reactive protein, IL-6 and D-dimer); microbial translocation (lipopolysaccharide, 16S rDNA, lipopolysaccharide-binding protein and soluble CD14); and immune dysfunction of specific cellular subsets (T cells, natural killer cells and monocytes) in HIV-infected patients on cART and their relationship to adverse clinical outcomes including impaired CD4 T-cell recovery, as well as non-AIDS clinical events, such as cardiovascular disease
AB - Here we review biomarkers of T-cell activation (CD69, -25 and -38, HLA-DR, and soluble CD26 and -30); generalized immune activation (C-reactive protein, IL-6 and D-dimer); microbial translocation (lipopolysaccharide, 16S rDNA, lipopolysaccharide-binding protein and soluble CD14); and immune dysfunction of specific cellular subsets (T cells, natural killer cells and monocytes) in HIV-infected patients on cART and their relationship to adverse clinical outcomes including impaired CD4 T-cell recovery, as well as non-AIDS clinical events, such as cardiovascular disease
M3 - Article
VL - 5
SP - 171
EP - 186
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 2
ER -
