L'imagerie par bioluminescence pour visualiser la progression tumorale et la métastase chez le petit animal

Alexandre Kauskot; Jan Manent; Fabrice Chareyre; Márcia Cominetti; Martine Chopin; Marco Giovannini; Chantal Legrand; Arnaud Bonnefoy

doi:10.1051/jbio:2007032

L'imagerie par bioluminescence pour visualiser la progression tumorale et la métastase chez le petit animal

Translated title of the contribution: Bioluminescent imaging to monitor tumor progression and metastasis in live animal

Alexandre Kauskot, Jan Manent, Fabrice Chareyre, Márcia Cominetti, Martine Chopin, Marco Giovannini, Chantal Legrand, Arnaud Bonnefoy

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Animal models allowing more sensitive and early detection of tumorigenesis and metastasis are instrumental in the fight for developing effective therapies against aggressive forms of cancer. In the present chapter, the advantages and limitations of the bioluminescent imaging (BLI) approach are discussed. Although BLI provides rapid, highly sensitive, noninvasive and quantitative detection of small tumors and micrometastases, several issues like the low anatomic resolution or the attenuation of the luminescent signal with tissue depth must be considered when using this technology.

Translated title of the contribution	Bioluminescent imaging to monitor tumor progression and metastasis in live animal
Original language	French
Pages (from-to)	223-228
Number of pages	6
Journal	Journal de la Societe de Biologie
Volume	201
Issue number	3
DOIs	https://doi.org/10.1051/jbio:2007032
Publication status	Published - 1 Dec 2007
Externally published	Yes

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AU - Kauskot, Alexandre

AU - Manent, Jan

AU - Chareyre, Fabrice

AU - Cominetti, Márcia

AU - Chopin, Martine

AU - Giovannini, Marco

AU - Legrand, Chantal

AU - Bonnefoy, Arnaud

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AB - Animal models allowing more sensitive and early detection of tumorigenesis and metastasis are instrumental in the fight for developing effective therapies against aggressive forms of cancer. In the present chapter, the advantages and limitations of the bioluminescent imaging (BLI) approach are discussed. Although BLI provides rapid, highly sensitive, noninvasive and quantitative detection of small tumors and micrometastases, several issues like the low anatomic resolution or the attenuation of the luminescent signal with tissue depth must be considered when using this technology.

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ER -

L'imagerie par bioluminescence pour visualiser la progression tumorale et la métastase chez le petit animal

Abstract

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