TY - JOUR
T1 - Biological variations of thirteen plasma biochemical indicators
AU - Qi, Zhihong
AU - Chen, Yu
AU - Zhang, Lin
AU - Ma, Xinming
AU - Wang, Fei
AU - Cheng, Qian
AU - Du, Juan
AU - Hao, Yingying
AU - Chi, Shuling
AU - Cui, Wei
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 81472029 and No. 81071418 ).
Publisher Copyright:
© 2015.
PY - 2016/1/15
Y1 - 2016/1/15
N2 - Background: Reports on biological variation of plasma biochemical indicators are limited. We evaluated biological variations of 13 plasma biochemical indicators. Methods: Plasma samples were collected from 40 healthy individuals over 5days. Intra-individual coefficient of variation (CVI), inter-individual coefficient of variation (CVG), index of individuality (II), reference change value (RCV), and analytical goal parameters were calculated. Results: Albumin (Alb) showed the lowest CVI (2.50%) and the lowest CVG (5.08%), while C-reactive protein (hsCRP) presented the highest CVI (26.87%) and CVG (61.73%). II values were all less than 1.0. Alb presented the lowest 95% RCV (7.67), while hsCRP showed the highest 95% RCV (74.61). Alb, urea, creatinine (Cr), creatine kinase (CK), and creatine kinase isoenzyme MB (CKMBmass) CVI differed with gender (P<0.05). The CVG of the 13 indicators presented a significant gender difference (P<0.0001). Alb showed the lowest desirable imprecision CV (1.3%), the lowest desirable bias (1.4%), and the lowest desirable total error (3.5%), while hsCRP presented the highest desirable imprecision (13.4%), the highest desirable bias (16.8%), and the highest desirable total error (39.0%). Conclusion: Our findings add to the database of biological variations of plasma indicators.
AB - Background: Reports on biological variation of plasma biochemical indicators are limited. We evaluated biological variations of 13 plasma biochemical indicators. Methods: Plasma samples were collected from 40 healthy individuals over 5days. Intra-individual coefficient of variation (CVI), inter-individual coefficient of variation (CVG), index of individuality (II), reference change value (RCV), and analytical goal parameters were calculated. Results: Albumin (Alb) showed the lowest CVI (2.50%) and the lowest CVG (5.08%), while C-reactive protein (hsCRP) presented the highest CVI (26.87%) and CVG (61.73%). II values were all less than 1.0. Alb presented the lowest 95% RCV (7.67), while hsCRP showed the highest 95% RCV (74.61). Alb, urea, creatinine (Cr), creatine kinase (CK), and creatine kinase isoenzyme MB (CKMBmass) CVI differed with gender (P<0.05). The CVG of the 13 indicators presented a significant gender difference (P<0.0001). Alb showed the lowest desirable imprecision CV (1.3%), the lowest desirable bias (1.4%), and the lowest desirable total error (3.5%), while hsCRP presented the highest desirable imprecision (13.4%), the highest desirable bias (16.8%), and the highest desirable total error (39.0%). Conclusion: Our findings add to the database of biological variations of plasma indicators.
KW - Analytical goal
KW - Biological variation
KW - Index of individuality
KW - Plasma biochemical indicator
KW - Reference change value
UR - https://www.scopus.com/pages/publications/84946615426
U2 - 10.1016/j.cca.2015.11.008
DO - 10.1016/j.cca.2015.11.008
M3 - Article
C2 - 26561925
AN - SCOPUS:84946615426
SN - 0009-8981
VL - 452
SP - 87
EP - 91
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
ER -