Biological effects of lysophosphatidic acid in the nervous system

Frisca Frisca, Roger A Sabbadini, Yona Goldshmit, Alice Pebay

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.
Original languageEnglish
Pages (from-to)273 - 322
Number of pages50
JournalInternational Review of Cell and Molecular Biology
Volume296
DOIs
Publication statusPublished - 2012

Cite this

Frisca, Frisca ; Sabbadini, Roger A ; Goldshmit, Yona ; Pebay, Alice. / Biological effects of lysophosphatidic acid in the nervous system. In: International Review of Cell and Molecular Biology. 2012 ; Vol. 296. pp. 273 - 322.
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author = "Frisca Frisca and Sabbadini, {Roger A} and Yona Goldshmit and Alice Pebay",
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Biological effects of lysophosphatidic acid in the nervous system. / Frisca, Frisca; Sabbadini, Roger A; Goldshmit, Yona; Pebay, Alice.

In: International Review of Cell and Molecular Biology, Vol. 296, 2012, p. 273 - 322.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Biological effects of lysophosphatidic acid in the nervous system

AU - Frisca, Frisca

AU - Sabbadini, Roger A

AU - Goldshmit, Yona

AU - Pebay, Alice

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AB - Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.

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