Abstract
| Original language | English |
|---|---|
| Title of host publication | Biointerfaces |
| Subtitle of host publication | Where Material Meets Biology |
| Editors | Dietmar Hutmacher, Wojciech Chrzanowski |
| Place of Publication | Cambridge UK |
| Publisher | The Royal Society of Chemistry |
| Chapter | 6 |
| Pages | 133-150 |
| Number of pages | 18 |
| ISBN (Electronic) | 9781782628453 |
| ISBN (Print) | 9781849738767 |
| DOIs | |
| Publication status | Published - 2015 |
| Externally published | Yes |
Publication series
| Name | RSC Smart Materials |
|---|---|
| Publisher | The Royal Society of Chemistry |
| Number | 10 |
| ISSN (Print) | 2046-0066 |
Cite this
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Biointerfaces between cells and substrates in three dimensions. / Hayward, Adam S.; Cameron, Neil R.; Przyborski, Stefan A.
Biointerfaces: Where Material Meets Biology. ed. / Dietmar Hutmacher; Wojciech Chrzanowski. Cambridge UK : The Royal Society of Chemistry, 2015. p. 133-150 (RSC Smart Materials; No. 10).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
TY - CHAP
T1 - Biointerfaces between cells and substrates in three dimensions
AU - Hayward, Adam S.
AU - Cameron, Neil R.
AU - Przyborski, Stefan A.
PY - 2015
Y1 - 2015
N2 - In order to successfully replicate native cell and tissue function in the laboratory, the artificial growth environment needs to be physiologically relevant. Traditionally, cells have been grown on plastic substrates such as a Petri dish that often forces cells to flatten out into a two-dimensional (2D) morphology. This approach is highly unrealistic and fails to replicate the complex 3D architecture and behaviour found in vivo. This chapter therefore describes some of the materials now available that offer cells a 3D interface for growth in vitro. A brief review of the advantages and disadvantages of each technology is discussed, along with some of the current methodologies available to ‘talk’ and ‘listen’ to cells in this new 3D environment. These methodologies are exemplified in this chapter with a practical case study using the Alvetex®Scaffold. Finally, a mention of the future developments of 3D substrates is also included, such as those 3D models that include various mechanical and biochemical properties representative of the native environment.
AB - In order to successfully replicate native cell and tissue function in the laboratory, the artificial growth environment needs to be physiologically relevant. Traditionally, cells have been grown on plastic substrates such as a Petri dish that often forces cells to flatten out into a two-dimensional (2D) morphology. This approach is highly unrealistic and fails to replicate the complex 3D architecture and behaviour found in vivo. This chapter therefore describes some of the materials now available that offer cells a 3D interface for growth in vitro. A brief review of the advantages and disadvantages of each technology is discussed, along with some of the current methodologies available to ‘talk’ and ‘listen’ to cells in this new 3D environment. These methodologies are exemplified in this chapter with a practical case study using the Alvetex®Scaffold. Finally, a mention of the future developments of 3D substrates is also included, such as those 3D models that include various mechanical and biochemical properties representative of the native environment.
UR - http://www.scopus.com/inward/record.url?scp=84934282328&partnerID=8YFLogxK
U2 - 10.1039/9781782628453-00133
DO - 10.1039/9781782628453-00133
M3 - Chapter (Book)
SN - 9781849738767
T3 - RSC Smart Materials
SP - 133
EP - 150
BT - Biointerfaces
A2 - Hutmacher, Dietmar
A2 - Chrzanowski, Wojciech
PB - The Royal Society of Chemistry
CY - Cambridge UK
ER -