Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: hydrogen bonding and photo-crosslinking study

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Abstract

Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)-b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxylmediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.
Original languageEnglish
Pages (from-to)4121 - 4128
Number of pages8
JournalJournal of Polymer Science, Part A: Polymer Chemistry
Volume49
Issue number19
DOIs
Publication statusPublished - 2011

Cite this

@article{001b9a73f0424a77abd46209477b5298,
title = "Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: hydrogen bonding and photo-crosslinking study",
abstract = "Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)-b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxylmediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.",
author = "Gagan Kaur and Lan-Yun Chang and Toby Bell and Hearn, {Milton Thomas William} and Kei Saito",
year = "2011",
doi = "10.1002/pola.24853",
language = "English",
volume = "49",
pages = "4121 -- 4128",
journal = "Journal of Polymer Science, Part A: Polymer Chemistry",
issn = "0887-624X",
publisher = "Wiley-Blackwell",
number = "19",

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TY - JOUR

T1 - Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: hydrogen bonding and photo-crosslinking study

AU - Kaur, Gagan

AU - Chang, Lan-Yun

AU - Bell, Toby

AU - Hearn, Milton Thomas William

AU - Saito, Kei

PY - 2011

Y1 - 2011

N2 - Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)-b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxylmediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

AB - Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)-b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxylmediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.

UR - http://onlinelibrary.wiley.com/doi/10.1002/pola.24853/pdf

U2 - 10.1002/pola.24853

DO - 10.1002/pola.24853

M3 - Article

VL - 49

SP - 4121

EP - 4128

JO - Journal of Polymer Science, Part A: Polymer Chemistry

JF - Journal of Polymer Science, Part A: Polymer Chemistry

SN - 0887-624X

IS - 19

ER -