Bioinspired core-bound polymeric micelles, based on hydrogen bonding and photo-crosslinking, of thymine have been prepared from poly(vinylbenzylthymine)-b-poly(vinylbenzyltriethylammonium chloride). The amphiphilic block copolymer was synthesized by 2,2-tetramethylpiperidin-1-oxylmediated living radical polymerization in water/ethylene glycol solution. Micelle characterization and critical micelle concentration measurements demonstrated that the hydrogen bonding of the attached thymine units stabilizes the micelles. Further, core-crosslinked polymeric micelles were formed by ultraviolet (UV) radiation showing that the stability of the micelle could be controlled by the UV crosslinking of the attached thymines.
|Pages (from-to)||4121 - 4128|
|Number of pages||8|
|Journal||Journal of Polymer Science, Part A: Polymer Chemistry|
|Publication status||Published - 2011|
Kaur, G., Chang, L-Y., Bell, T., Hearn, M. T. W., & Saito, K. (2011). Bioinspired core-crosslinked micelles from thymine-functionalized amphiphilic block copolymers: hydrogen bonding and photo-crosslinking study. Journal of Polymer Science, Part A: Polymer Chemistry, 49(19), 4121 - 4128. https://doi.org/10.1002/pola.24853