Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 827 - 836 |
| Number of pages | 10 |
| Journal | International Journal for Parasitology |
| Volume | 44 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Bioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes. / Breugelmans, Bert; Jex, Aaron R; Korhonen, Pasi K; Mangiola, Stefano; Young, Neil D; Sternberg, Paul; Boag, Peter R; Hofmann, Andreas; Gasser, Robin Beat.
In: International Journal for Parasitology, Vol. 44, No. 11, 2014, p. 827 - 836.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Bioinformatic exploration of RIO protein kinases of parasitic and free-living nematodes
AU - Breugelmans, Bert
AU - Jex, Aaron R
AU - Korhonen, Pasi K
AU - Mangiola, Stefano
AU - Young, Neil D
AU - Sternberg, Paul
AU - Boag, Peter R
AU - Hofmann, Andreas
AU - Gasser, Robin Beat
PY - 2014
Y1 - 2014
N2 - Despite right open reading frame kinases being essential for life, their functions, substrates and cellular pathways remain enigmatic. In the present study, gene structures were characterised for 26 right open reading frame kinase from draft genomes of parasitic and free-living nematodes. RNA-seq transcription profiles of right open reading frame kinase genes were investigated for selected parasitic nematodes and showed that these kinases are transcribed in developmental stages that infect their mammalian host. Three-dimensional structural models of Caenorhabditis elegans right open reading frame kinases were predicted, and elucidated functional domains and conserved regions in nematode homologs. These findings provide prospects for functional studies of RIO kinase genes in C. elegans and an opportunity for the design and validation of nematode-specific inhibitors of these enzymes in socioeconomic parasitic worms.
AB - Despite right open reading frame kinases being essential for life, their functions, substrates and cellular pathways remain enigmatic. In the present study, gene structures were characterised for 26 right open reading frame kinase from draft genomes of parasitic and free-living nematodes. RNA-seq transcription profiles of right open reading frame kinase genes were investigated for selected parasitic nematodes and showed that these kinases are transcribed in developmental stages that infect their mammalian host. Three-dimensional structural models of Caenorhabditis elegans right open reading frame kinases were predicted, and elucidated functional domains and conserved regions in nematode homologs. These findings provide prospects for functional studies of RIO kinase genes in C. elegans and an opportunity for the design and validation of nematode-specific inhibitors of these enzymes in socioeconomic parasitic worms.
UR - http://www.sciencedirect.com/science/article/pii/S0020751914001490
U2 - 10.1016/j.ijpara.2014.06.005
DO - 10.1016/j.ijpara.2014.06.005
M3 - Article
VL - 44
SP - 827
EP - 836
JO - International Journal for Parasitology
JF - International Journal for Parasitology
SN - 0020-7519
IS - 11
ER -