Biogenesis, regulation, and targeting of the Type III secretion system

Thierry Izore, Viviana Job, Andrea Dessen

Research output: Contribution to journalReview ArticleResearchpeer-review

86 Citations (Scopus)

Abstract

The type III secretion system (T3SS) is employed by a number of Gram-negative bacterial pathogens to inject toxins into eukaryotic cells. The biogenesis of this complex machinery requires the regulated interaction between over 20 cytosolic, periplasmic, and membrane-imbedded proteins, many of which undergo processes such as polymerization, partner recognition, and partial unfolding. Elements of this intricate macromolecular system have been characterized through electron microscopy, crystallography, and NMR techniques, allowing for an initial understanding of the spatiotemporal regulation of T3SS-related events. Here, we report recent advances in the structural characterization of T3SS proteins from a number of bacteria, and provide an overview of recently identified small molecule T3SS inhibitors that could potentially be explored for novel antibacterial development.
Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalStructure
Volume19
Issue number5
DOIs
Publication statusPublished - 11 May 2011
Externally publishedYes

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