Biofunctional Dairy Protein Fractions

H. Roginski, L. Bennett, H. Korhonen, S. F. Gauthier, Y. Pouliot, Brad W. Woonton

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)


Milk proteins and peptides that produce defined biological effects are briefly characterised in this chapter. These include (i) anti‐hypertensive, anti‐thrombotic, immunomodulatory, opioid receptor‐binding, and metal‐binding peptides; (ii) proteins and peptides with antimicrobial and antiviral activity, (iii) immunoglobulins of colostrum and milk; (iv) milk growth factors and (v) glycomacropeptide.

The mode of action of these proteins and peptides is outlined and the evidence of their in vivo efficacy, if available, reviewed. Their current and potential practical applications are assessed.

A complex picture emerges from this review as some of the peptides studied elicit multiple physiological responses. A number of products containing dairy derived bioactive peptides are already on the market, such as fermented milk products with ACE‐inhibitory peptides. Other products, such as GMP‐based foods for people with special dietary needs, are likely to be commercialised in the near future.

The objectives of further studies on milk‐derived proteins and peptides will include validating their physiological efficacy in humans and improving technologies for their isolation and purification.
Original languageEnglish
Title of host publicationAdvances in Dairy Ingredients
EditorsGeoffrey W. Smithers, Mary Ann Augustin
Place of PublicationAmes IA USA
Number of pages38
ISBN (Print)9780813823959
Publication statusPublished - 10 Jan 2013
Externally publishedYes


  • Anti-hypertensive peptides
  • Anti-thrombotic peptides
  • Basic fibroblast growth factor (bFGF/FGF2)
  • Epidermal growth factor (EGF)
  • Glycomacropeptide
  • Immunomodulatory peptides
  • Insulin-like growth factor-I (IGF-I)
  • Kappacin
  • Lactoferrampin
  • Lactoferricin
  • Lactoferrin
  • Lactoperoxidase
  • Lysozyme
  • Metal-binding peptides
  • Milk allergy
  • Milk and colostrum immunoglobulins
  • Opioid receptor-binding peptides
  • Phenylketonuria
  • Protein and peptide modification
  • Transforming growth factor-beta 2 (TGF-β2)
  • Xanthine oxidase

Cite this