Bioengineering artificial blood vessels from natural materials

Matthew J. Moore, Richard P. Tan, Nianji Yang, Jelena Rnjak-Kovacina, Steven G. Wise

Research output: Contribution to journalReview ArticleResearchpeer-review

41 Citations (Scopus)

Abstract

Bioengineering an effective, small diameter (<6 mm) artificial vascular graft for use in bypass surgery when autologous grafts are unavailable remains a persistent challenge. Commercially available grafts are typically made from plastics, which have high strength but lack elasticity and present a foreign surface that triggers undesirable biological responses. Tissue engineered grafts, leveraging decellularized animal vessels or derived de novo from long-term cell culture, have dominated recent research, but failed to meet clinical expectations. More effective constructs that are readily translatable are urgently needed. Recent advances in natural materials have made the production of robust acellular conduits feasible and their use increasingly attractive. Here, we identify a subset of natural materials with potential to generate durable, small diameter vascular grafts.

Original languageEnglish
Pages (from-to)693-707
Number of pages15
JournalTrends in Biotechnology
Volume40
Issue number6
DOIs
Publication statusPublished - Jun 2022
Externally publishedYes

Keywords

  • blood vessels
  • cardiovascular disease
  • remodeling
  • translation
  • vascular graft

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