Biodistribution of polymer hydrogel capsules for the delivery of therapeutics

Tracey M Hinton, Paul Monaghan, Diane Green, Sander A A Kooijmans, Shuning Shi, Kerry Breheney, Mark L Tizard, Joseph Nicolazzo, Alexander N Zelikin, Kim Wark

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Abstract

A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed at tracking a potential delivery vehicle for therapeutic agents, including vaccine peptides and drugs derived from poly(methacrylic acid) hydrogel capsules in certain organs and cell types.
Original languageEnglish
Pages (from-to)3251 - 3260
Number of pages10
JournalActa Biomaterialia
Volume8
Issue number9
DOIs
Publication statusPublished - 2012

Cite this

Hinton, T. M., Monaghan, P., Green, D., Kooijmans, S. A. A., Shi, S., Breheney, K., Tizard, M. L., Nicolazzo, J., Zelikin, A. N., & Wark, K. (2012). Biodistribution of polymer hydrogel capsules for the delivery of therapeutics. Acta Biomaterialia, 8(9), 3251 - 3260. https://doi.org/10.1016/j.actbio.2012.05.028