A key phase in the development of intelligently designed nanoparticle delivery vehicles for new therapeutic agents is to gain an understanding of their interaction with tissues and cells. We report a series of in vitro and in vivo experiments aimed at tracking a potential delivery vehicle for therapeutic agents, including vaccine peptides and drugs derived from poly(methacrylic acid) hydrogel capsules in certain organs and cell types.
Hinton, T. M., Monaghan, P., Green, D., Kooijmans, S. A. A., Shi, S., Breheney, K., Tizard, M. L., Nicolazzo, J., Zelikin, A. N., & Wark, K. (2012). Biodistribution of polymer hydrogel capsules for the delivery of therapeutics. Acta Biomaterialia, 8(9), 3251 - 3260. https://doi.org/10.1016/j.actbio.2012.05.028