Biodegradable polyurethanes: Design, synthesis, properties and potential applications

Pathiraja A. Gunatillake, Raju Adhikari

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Abstract

This chapter reviews recent developments in biodegradable polyurethanes forapplications in regenerative medicine and biomedical implants. A brief introduction tothe chemistry, synthesis and structure property relationships in biodegradablepolyurethanes developed for biomedical applications is provided. Numerous formulationstrategies to address the mechanical property and biodegradability requirements forapplications in cardiovascular, orthopedic and nerve regeneration are reviewed toillustrate the structure-property-function relationships of biodegradable polyurethanes.Fabrication of scaffolds using processing techniques such as electrospinning andtemperature-induced phase separation is discussed. The compatibility, growth andproliferation of osteoblasts, chondrocytes, fibroblasts, endothelial cells, smooth musclecells, and stem cells are summarized to demonstrate the suitability of polyurethanescaffolds for tissue engineering applications. Long-term in-vivo studies to demonstratethe functional performance, safety and biodegradation of polyurethane implants aresummarized to illustrate the potential advantages of this class of polymers for emergingapplications in tissue engineering and the next generation of biomedical implants.

Original languageEnglish
Title of host publicationBiodegradable Polymers
Subtitle of host publicationProcessing, Degradation and Applications
PublisherNova Science Publishers
Pages431-470
Number of pages40
ISBN (Print)9781612095349
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Aliphatic diisocyanates
  • Biocompatibility
  • Biodegradable polyurethanes
  • Biodegradation
  • Cardiovascular
  • Mechanical properties
  • Medical implants
  • Nerve regeneration
  • Orthopedic
  • Polyester polyols
  • Regenerative medicine
  • Tissue engineering

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