Projects per year
Abstract
The blood-brain barrier (BBB), formed by endothelial cells lining the cerebral microvessels, remains a formidable challenge for the delivery of many therapeutics into the central nervous system (CNS). In an attempt to enhance the CNS disposition of therapeutics, which either have poor inherent permeability across the BBB or whose brain uptake is limited by the function of efflux transporters, a multitude of polymeric nanocarriers have been exploited. Common natural and synthetic polymers used for the development of these nanocarriers include polysaccharides, poly(alkylcyanoacrylate)s, and polyesters such as poly(lactic-co-glycolic acid). To avoid recognition by circulating macrophages and, therefore, minimize their systemic clearance, these polymeric nanocarriers are often coated with polyethylene glycol or emulsifiers such as polysorbate 80, and to enhance their targeting to the BBB, addition of various targeting entities such as antibodies to brain microvascular receptor-mediated transporters is common. Unlike liposomes however, polymeric nanoparticles are more stable, allow for a detailed control of the carrier properties (e.g., size, shape, charge, surface morphology and chemistry), facilitate the delivery of a range of different cargoes with high capacities, and can be engineered with different drug release mechanisms and modified with various targeting ligands. This chapter will provide an up-to-date account on the various polymeric nanoparticle approaches which have been exploited to target therapeutics to the CNS, with particular focus on biodegradable polymers and practical techniques that can be employed for the preparation of these polymeric nanoparticles.
Original language | English |
---|---|
Title of host publication | Nanomedicines for Brain Drug Delivery |
Editors | Javier O Morales, Pieter J Gaillard |
Place of Publication | New York NY USA |
Publisher | Humana Press |
Chapter | 1 |
Pages | 1-27 |
Number of pages | 27 |
ISBN (Electronic) | 9781071608388 |
ISBN (Print) | 9781071608371 |
DOIs | |
Publication status | Published - 2021 |
Publication series
Name | Neuromethods |
---|---|
Volume | 157 |
ISSN (Print) | 0893-2336 |
ISSN (Electronic) | 1940-6045 |
Keywords
- Blood-brain barrier
- Nanoparticle
- PLGA
- Polymer
- Surface coating
- Targeting
Projects
- 1 Finished
-
ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
Davis, T., Boyd, B., Bunnett, N., Porter, C., Caruso, F., Kent, S., Thordarson, P., Kearnes, M., Gooding, J., Kavallaris, M., Thurecht, K., Whittaker, A., Parton, R., Corrie, S. R., Johnston, A., McGhee, J., Greguric, I. D., Stevens, M. M., Lewis, J., Lee, D. S., Alexander, C., Dawson, K., Hawker, C., Haddleton, D., Thierry, B., Prestidge, C. A., Meyer, A., Jones-Jayasinghe, N., Voelcker, N. H., Nann, T. & McLean, K.
Australian Research Council (ARC), Monash University, University of Melbourne, University of New South Wales, University of Queensland , University of South Australia, Monash University – Internal Faculty Contribution, University of Wisconsin Madison, Memorial Sloan Kettering Cancer Center, University of California System, University College Dublin, Imperial College London, University of Warwick, SungKyunKwan University, Australian Nuclear Science and Technology Organisation (ANSTO) , University of Nottingham
30/06/14 → 29/06/21
Project: Research