TY - JOUR
T1 - Biocompatible MXene-reinforced molecularly imprinted membranes for simultaneous filtration and acetaminophen capture
AU - Bacal, Christine Jurene O.
AU - Usman, Ken Aldren S.
AU - Rashed, Ahmed O.
AU - Maina, James W.
AU - Sharp, Julie A.
AU - Greene, George W.
AU - Nandurkar, Harshal H.
AU - Dwyer, Karen M.
AU - Razal, Joselito M.
AU - Dumée, Ludovic F.
N1 - Funding Information:
The authors acknowledge the Deakin University Institute for Frontier Materials (IFM) Advanced Characterization Facility, IFM Biological Laboratories, and IFM technical officers.
Publisher Copyright:
© 2024 Elsevier B.V.
PY - 2024/11/25
Y1 - 2024/11/25
N2 - In this study, the fabrication of biocompatible MXene-reinforced imprinted membranes (MX-AIM) capable of selectively capturing acetaminophen (APAP) molecules during filtration was demonstrated. The incorporation of MXene into a polymeric support membrane led to an overall improvement in both mechanical integrity and surface reactivity of the resulting composite, subsequently allowing efficient deposition of a molecularly imprinted polymer (MIP) layer on its surface. The synergy between the high surface reactivities of MXenes and the MIP layer rendered more adsorption sites, leading to the capture of approximately 32 % APAP on MX-AIM from a 200 ppm drug feed solution, compared to only ∼2 % for directly imprinted membranes. Additionally, these MXene-modified membranes exhibited high cell viabilities when tested against human monocytic cells, reaching up to >190 % cell proliferation. Overall, this research offers important insights on incorporating MXene nanofillers into membrane production, with the potential to overcome the challenges associated with applying the molecular imprinting technique to enhance the functionality of polymer materials.
AB - In this study, the fabrication of biocompatible MXene-reinforced imprinted membranes (MX-AIM) capable of selectively capturing acetaminophen (APAP) molecules during filtration was demonstrated. The incorporation of MXene into a polymeric support membrane led to an overall improvement in both mechanical integrity and surface reactivity of the resulting composite, subsequently allowing efficient deposition of a molecularly imprinted polymer (MIP) layer on its surface. The synergy between the high surface reactivities of MXenes and the MIP layer rendered more adsorption sites, leading to the capture of approximately 32 % APAP on MX-AIM from a 200 ppm drug feed solution, compared to only ∼2 % for directly imprinted membranes. Additionally, these MXene-modified membranes exhibited high cell viabilities when tested against human monocytic cells, reaching up to >190 % cell proliferation. Overall, this research offers important insights on incorporating MXene nanofillers into membrane production, with the potential to overcome the challenges associated with applying the molecular imprinting technique to enhance the functionality of polymer materials.
KW - Acetaminophen remediation
KW - Biocompatible MXene membrane
KW - Molecular imprinted membrane
KW - MXene-reinforced membrane
UR - https://www.scopus.com/pages/publications/85192088226
U2 - 10.1016/j.seppur.2024.127663
DO - 10.1016/j.seppur.2024.127663
M3 - Article
AN - SCOPUS:85192088226
SN - 1383-5866
VL - 348
JO - Separation and Purification Technology
JF - Separation and Purification Technology
M1 - 127663
ER -