Biochemical and pharmacological characterization of isatin and its derivatives: From structure to activity

Parvaneh Pakravan, Soheila Kashanian, Mohammad M. Khodaei, Frances J. Harding

Research output: Contribution to journalReview ArticleResearchpeer-review

149 Citations (Scopus)


Isatin, 1H-indole-2,3-dione, is a heterocyclic compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, a precursor for a large number of pharmacologically active compounds. Isatin and its derivatives have aroused great attention in recent years due to their wide variety of biological activities, relevant to application as insecticides and fungicides and in a broad range of drug therapies, including anticancer drugs, antibiotics and antidepressants. The purpose of this review is to provide an overview of the pharmacological activities of isatin and its synthetic and natural derivatives. Molecular modifications to tailor the properties of isatin and its derivatives are also discussed.

Original languageEnglish
Pages (from-to)313-335
Number of pages23
JournalPharmacological Reports
Issue number2
Publication statusPublished - 2013
Externally publishedYes


  • Anticancer
  • Anticonvulsant
  • Antimicrobial
  • Antioxidant
  • Derivatives
  • DNA and HSA binding
  • Isatin

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