Bioapplications of small molecule Aza-BODIPY: From rational structural design to: From vivo investigations

Zhenxiong Shi, Xu Han, Wenbo Hu, Hua Bai, Bo Peng, Lei Ji, Quli Fan, Lin Li, Wei Huang

Research output: Contribution to journalReview ArticleResearchpeer-review

318 Citations (Scopus)

Abstract

Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different disciplinary backgrounds would benefit from a review that provides a timely summary and outlook regarding Aza-BODIPY dyes. In this review, we report on the latest advances of Aza-BODIPY dyes, along with the empirical design guidelines and photophysical property manipulation of these dyes. In addition, we will discuss the biological applications of Aza-BODIPY dyes in probing various biological activities, as well as in fluorescence bioimaging/detection, newly-emerging photoacoustic bioimaging/detection, and phototherapy together with future challenges and implications in this field. We aim at providing an insightful design guideline and a clear overview of Aza-BODIPY dyes, which might entice new ideas and directions. This journal is

Original languageEnglish
Pages (from-to)7533-7567
Number of pages35
JournalChemical Society Reviews
Volume49
Issue number21
DOIs
Publication statusPublished - 7 Nov 2020
Externally publishedYes

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