TY - JOUR
T1 - Bioapplications of small molecule Aza-BODIPY
T2 - From rational structural design to: From vivo investigations
AU - Shi, Zhenxiong
AU - Han, Xu
AU - Hu, Wenbo
AU - Bai, Hua
AU - Peng, Bo
AU - Ji, Lei
AU - Fan, Quli
AU - Li, Lin
AU - Huang, Wei
PY - 2020/11/7
Y1 - 2020/11/7
N2 - Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different disciplinary backgrounds would benefit from a review that provides a timely summary and outlook regarding Aza-BODIPY dyes. In this review, we report on the latest advances of Aza-BODIPY dyes, along with the empirical design guidelines and photophysical property manipulation of these dyes. In addition, we will discuss the biological applications of Aza-BODIPY dyes in probing various biological activities, as well as in fluorescence bioimaging/detection, newly-emerging photoacoustic bioimaging/detection, and phototherapy together with future challenges and implications in this field. We aim at providing an insightful design guideline and a clear overview of Aza-BODIPY dyes, which might entice new ideas and directions. This journal is
AB - Boron-dipyrromethene (BODIPY) belongs to a family of organoboron compounds, commercialized as fluorescent dyes by Invitrogen™. As BODIPY derivatives, Aza-boron-dipyrromethene (Aza-BODIPY) dyes display superior spectral performances, such as red-shifted spectra and high molar extinction coefficients, and are considered to be extremely attractive organic materials for various bioapplications. Therefore, scientists from different disciplinary backgrounds would benefit from a review that provides a timely summary and outlook regarding Aza-BODIPY dyes. In this review, we report on the latest advances of Aza-BODIPY dyes, along with the empirical design guidelines and photophysical property manipulation of these dyes. In addition, we will discuss the biological applications of Aza-BODIPY dyes in probing various biological activities, as well as in fluorescence bioimaging/detection, newly-emerging photoacoustic bioimaging/detection, and phototherapy together with future challenges and implications in this field. We aim at providing an insightful design guideline and a clear overview of Aza-BODIPY dyes, which might entice new ideas and directions. This journal is
UR - http://www.scopus.com/inward/record.url?scp=85094983700&partnerID=8YFLogxK
U2 - 10.1039/d0cs00234h
DO - 10.1039/d0cs00234h
M3 - Review Article
C2 - 32996497
AN - SCOPUS:85094983700
SN - 0306-0012
VL - 49
SP - 7533
EP - 7567
JO - Chemical Society Reviews
JF - Chemical Society Reviews
IS - 21
ER -