Bioactive mimetics of conotoxins and other venom peptides

Peter J Duggan, Kellie Louise Tuck

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode of delivery and narrow therapeutic window cause complications for patients. This review will summarize progress in the development of small molecule, non-peptidic mimics of Conotoxins and a small number of other venom peptides. This will include a description of how some of the initially designed mimics have been modified to improve their drug-like properties
Original languageEnglish
Pages (from-to)4175-4198
Number of pages24
JournalToxins
Volume7
Issue number10
DOIs
Publication statusPublished - 2015

Keywords

  • venom peptides
  • toxins
  • conotoxins
  • peptidomimetics
  • N-type calcium channel
  • Cav2.2

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