Bioactive compounds: Natural defense against cancer?

Shonia Subramaniam, Kanga Rani Selvaduray, Ammu Kutty Radhakrishnan

Research output: Contribution to journalReview ArticleResearchpeer-review

70 Citations (Scopus)

Abstract

Cancer is a devastating disease that has claimed many lives. Natural bioactive agents from plants are gaining wide attention for their anticancer activities. Several studies have found that natural plant-based bioactive compounds can enhance the efficacy of chemotherapy, and in some cases ameliorate some of the side-effects of drugs used as chemotherapeutic agents. In this paper, we have reviewed the literature on the anticancer effects of four plant-based bioactive compounds namely, curcumin, myricetin, geraniin and tocotrienols (T3) to provide an overview on some of the key findings that are related to this effect. The molecular mechanisms through which the active compounds may exert their anticancer properties in cell and animal-based studies also discussed.

Original languageEnglish
Article number758
Number of pages15
JournalBiomolecules
Volume9
Issue number12
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Anticancer
  • Bioactive compounds
  • Curcumin
  • Geraniin
  • Myricetin
  • Tocotrienols

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