Bing-Neel syndrome – Bilateral cavernous sinus lymphoma causing visual failure

Chengde Pham, James D. Griffiths, Anthony Kam, Martin K. Hunn

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)


We report the case of a 68-year-old male with right eye vision loss secondary to a compressive optic neuropathy from Waldenstrom macroglobulinaemia relapse in both cavernous sinuses. Central nervous system involvement is extremely uncommon in lymphoplasmacytic lymphoma. Known as Bing-Neel syndrome, this has not been previously reported to present simultaneously in bilateral cavernous sinuses. We discuss the pathophysiology, diagnostic and neuroradiological features of Bing-Neel syndrome. In this case, there was marked clinical and radiological response to chemotherapy. As outcomes following treatment for Waldenstrom macroglobulinaemia improve, greater awareness of its less common manifestations becomes important. Neurosurgical intervention may be indicated to obtain histological diagnosis or decompress critical structures.

Original languageEnglish
Pages (from-to)134-135
Number of pages2
JournalJournal of Clinical Neuroscience
Publication statusPublished - Nov 2017


  • Bing-Neel syndrome
  • Cavernous sinus
  • Central nervous system
  • Lymphoma
  • Vision
  • Waldenstrom macroglobulinaemia

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