Binding of intimin from enteropathogenic Escherichia coli to lymphocytes and its functional consequences

Nathalie S. Gonçalves, Christine Hale, Gordon Dougan, Gad Frankel, Thomas T. MacDonald

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

Intimin-conjugated fluorescent beads bind to spleen CD4 T cells and Peyer's patch, mesenteric lymph node, and cecal follicle lymphocytes, with less binding to lamina propria T cells and intraepithelial lymphocytes. Intimin costimulates proliferation of spleen CD4 T cells and cells from organized lymphoid tissues but does not costimulate cells from the lamina propria of normal or inflamed colon.

Original languageEnglish
Pages (from-to)2960-2965
Number of pages6
JournalInfection and Immunity
Volume71
Issue number5
DOIs
Publication statusPublished - 1 May 2003
Externally publishedYes

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